Resting state signal latency predicts laterality in pediatric medically refractory temporal lobe epilepsy.
Resting state signal latency predicts laterality in pediatric medically refractory temporal lobe epilepsy.
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DOI：
10.1007/s00381-018-3770-5
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Smyth MD
中科院分区：
文献类型：
--
作者：
Shah MN;Mitra A;Goyal MS;Snyder AZ;Zhang J;Shimony JS;Limbrick DD;Raichle ME;Smyth MD
颞叶癫痫（TLE）影响成年人的静息状态脑网络。本研究旨在将儿童TLE患者的静息状态功能MRI（rsMRI）信号潜伏期与其偏侧性相关联。从2006年到2016年，对26例平均年龄为10.7岁（范围0.9-18岁）的手术TLE患者（12例左侧，14例右侧）进行了前瞻性研究。术前rsMRI在具有一致的偏侧结构MRI、EEG和PET研究的患者中获得。进行标准预处理技术和基于种子的rsMRI分析。此外，检查每个6 mm采样体素之间的rsMRI信号的延迟，与全局平均信号进行比较，并投影到个体和队列的标准图谱空间上。除1例患者外，所有26例患者术后癫痫发作频率均有所改善，平均随访2.9年（范围0-7.7年），21例患者无癫痫发作。当按致痫偏侧性分组时，潜伏期图定性地表明，与右颞叶的整体平均信号相比，右颞叶患者具有相对较早的信号模式，而左颞叶患者具有相对较晚的信号模式。定量分析显示，两组患者双侧颞叶的信号潜伏期簇有显著性差异（P<0.001）。医学难治性儿童TLE患者存在功能性MR信号潜伏期变化。在右侧TLE患者中，右侧颞叶中的信号潜伏期先于平均信号，而在左侧TLE患者中延迟。通过更大规模的验证性研究，术前rsMRI潜伏期分析可能提供一种廉价、无创的辅助方式来确定儿童TLE的侧限。
Temporal lobe epilepsy (TLE) affects resting state brain networks in adults. This study aims to correlate resting state functional MRI (rsMRI) signal latency in pediatric TLE patients with their laterality. From 2006 to 2016, 26 surgical TLE patients (12 left, 14 right) with a mean age of 10.7 years (range 0.9–18) were prospectively studied. Preoperative rsMRI was obtained in patients with concordant lateralizing structural MRI, EEG and PET studies. Standard preprocessing techniques and seed-based rsMRI analyses were performed. Additionally, the latency in rsMRI signal between each 6 mm voxel sampled was examined, compared to the global mean signal, and projected onto standard atlas space for individuals and the cohort. All but one of the 26 patients improved seizure frequency postoperatively with a mean follow-up of 2.9 years (range 0–7.7), with 21 patients seizure-free. When grouped for epileptogenic laterality, the latency map qualitatively demonstrated that the right TLE patients had a relatively early signal pattern whereas the left TLE patients had a relatively late signal pattern compared to the global mean signal in the right temporal lobe. Quantitatively, the two groups had significantly different signal latency clusters in the bilateral temporal lobes (p<0.001). There are functional MR signal latency changes in medical refractory pediatric TLE patients. Qualitatively, signal latency in the right temporal lobe precedes the mean signal in right TLE patients and is delayed in left TLE patients. With larger confirmatory studies, preoperative rsMRI latency analysis may offer an inexpensive, noninvasive adjunct modality to lateralize pediatric TLE.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.4
作者：
Constable RT;Scheinost D;Finn ES;Shen X;Hampson M;Winstanley FS;Spencer DD;Papademetris X
通讯作者：
Papademetris X
影响因子：
14.5
作者：
Gleissner, U;Sassen, R;Helmstaedter, C
通讯作者：
Helmstaedter, C
影响因子：
1.9
作者：
Arya, Ravindra;Tenney, Jeffrey R.;Mangano, Francesco T.
通讯作者：
Mangano, Francesco T.
影响因子：
5.7
作者：
Hacker CD;Laumann TO;Szrama NP;Baldassarre A;Snyder AZ;Leuthardt EC;Corbetta M
通讯作者：
Corbetta M