Action selection: a race model for selected and non-selected actions distinguishes the contribution of premotor and prefrontal areas.
Action selection: a race model for selected and non-selected actions distinguishes the contribution of premotor and prefrontal areas.
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DOI：
10.1016/j.neuroimage.2010.02.045
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发表时间：
2010-06
期刊：
影响因子：
5.7
通讯作者：
Nimmo-Smith, I.
中科院分区：
文献类型：
--
作者：
Rowe, J. B.;Hughes, L.;Nimmo-Smith, I.
种族模型已被用来解释知觉，运动和视觉的决定。在这里，我们开发了一个种族模型来解释当没有明显的奖励和外部线索来指定要做什么动作时，人类受试者是如何选择动作的。重要的是，我们能够估计选择和非选择行为的神经元决策单位的累积活动。我们使用功能性磁共振成像（fMRI）来测试与这个种族模型的预测相关的局部大脑活动。根据种族模型，SMA前区、扣带运动区和运动前区的活动与反应之间的前瞻性选择相关。外侧前额叶皮层的活动与种族模型无关，尽管这一区域在行动选择期间是活跃的。这种活动与个体在不同行动之间转换的程度有关。至关重要的是，一项后续实验表明，它在第一次试验中并不存在。综上所述，这些结果表明，外侧前额叶皮层不是产生行动的来源。它更有可能参与转向替代品或监测以前的行动。因此，我们的实验显示了种族模型在区分行动选择中不同区域的贡献方面的能力。
Race models have been used to explain perceptual, motor and oculomotor decisions. Here we developed a race model to explain how human subjects select actions when there are no overt rewards and no external cues to specify which action to make. Critically, we were able to estimate the cumulative activity of neuronal decision-units for selected and non-selected actions. We used functional magnetic resonance imaging (fMRI) to test for regional brain activity that correlated with the predictions of this race model. Activity in the pre-SMA, cingulate motor and premotor areas correlated with prospective selection between responses according to the race model. Activity in the lateral prefrontal cortex did not correlate with the race model, even though this area was active during action selection. This activity related to the degree to which individuals switched between alternative actions. Crucially, a follow-up experiment showed that it was not present on the first trial. Taken together, these results suggest that the lateral prefrontal cortex is not the source for the generation of action. It is more likely that it is involved in switching to alternatives or monitoring previous actions. Thus, our experiment shows the power of the race model in distinguishing the contribution of different areas in the selection of action.
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影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
5.7
作者：
Cunnington, R;Windischberger, C;Moser, E
通讯作者：
Moser, E
影响因子：
16.2
作者：
Beck JM;Ma WJ;Kiani R;Hanks T;Churchland AK;Roitman J;Shadlen MN;Latham PE;Pouget A
通讯作者：
Pouget A
影响因子：
5.7
作者：
Jahanshahi, M;Dirnberger, G;Frith, CD
通讯作者：
Frith, CD
DOI：
10.1523/jneurosci.4515-08.2009
发表时间：
2009-04-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Croxson PL;Walton ME;O'Reilly JX;Behrens TE;Rushworth MF
通讯作者：
Rushworth MF