Searching for signatures of sexually antagonistic selection on stickleback sex chromosomes.

Searching for signatures of sexually antagonistic selection on stickleback sex chromosomes.
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DOI:
10.1098/rstb.2021.0205
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发表时间:
2022-08
影响因子:
6.3
通讯作者:
Peichel, Catherine L.
Peichel, Catherine L.
中科院分区:
生物学1区
文献类型:
--
作者:
Dagilis, Andrius J.;Sardell, Jason M.;Josephson, Matthew P.;Su, Yiheng;Kirkpatrick, Mark;Peichel, Catherine L.

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当一个等位基因对一种性别有利而对另一种性别有害时,发生基因座内性拮抗选择。这种形式的选择被认为是性染色体进化的关键,但很难检测到。在这里,我们进行了分析相年轻的性染色体,寻找在日本海刺鱼(Gasterosteus nipponicus)的性拮抗选择的信号。定相使我们能够确定性染色体上重组抑制的日期,并提供了前所未有的分辨率来识别染色体重组区域中的性拮抗选择。我们确定了四个窗口,在重组区域的X和Y之间的分歧升高,所有在或非常接近的基因与表型可能在人类的性拮抗选择。然而,我们不能排除另一种假设,即差异的峰值是由人口影响造成的。因此,尽管性拮抗选择是性染色体上超基因形成的一个关键假设,但它仍然具有挑战性。这篇文章是“超基因的基因组结构:原因和进化的后果”的主题问题的一部分。
Intralocus sexually antagonistic selection occurs when an allele is beneficial to one sex but detrimental to the other. This form of selection is thought to be key to the evolution of sex chromosomes but is hard to detect. Here we perform an analysis of phased young sex chromosomes to look for signals of sexually antagonistic selection in the Japan Sea stickleback (Gasterosteus nipponicus). Phasing allows us to date the suppression of recombination on the sex chromosome and provides unprecedented resolution to identify sexually antagonistic selection in the recombining region of the chromosome. We identify four windows with elevated divergence between the X and Y in the recombining region, all in or very near genes associated with phenotypes potentially under sexually antagonistic selection in humans. We are unable, however, to rule out the alternative hypothesis that the peaks of divergence result from demographic effects. Thus, although sexually antagonistic selection is a key hypothesis for the formation of supergenes on sex chromosomes, it remains challenging to detect. This article is part of the theme issue ‘Genomic architecture of supergenes: causes and evolutionary consequences’.
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