Extracellular Vesicles Regulated by Viruses and Antiviral Strategies.
Extracellular Vesicles Regulated by Viruses and Antiviral Strategies.
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DOI：
10.3389/fcell.2021.722020
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发表时间：
2021
影响因子：
5.5
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Yang L;Li J;Li S;Dang W;Xin S;Long S;Zhang W;Cao P;Lu J
细胞外小泡(EVS)由外体、微泡和其他小泡组成，主要来源于多囊泡体(MVB)途径或质膜。电动汽车作为细胞间通讯的中介工具越来越受到人们的认可，并与人类健康密切相关。病毒感染与各种疾病有关，包括呼吸系统疾病、神经疾病和癌症。越来越多的研究表明，病毒可以通过调节EVS的组成和功能来调节其感染能力和致病性。非编码RNA(Non-Coding RNA，ncRNA)分子往往是病毒的靶标，也是病毒相关EV的主要功能载体，在靶细胞的表观遗传调控中具有重要作用。本文综述了病毒调控下EVS的研究进展，重点介绍了病毒调控EVS的内容变化和功能，强调了病毒感染背景下EVS的分离方法，以及基于其使用的潜在抗病毒策略。该综述将促进对病毒致病机制的认识和抗病毒研究的发展。
Extracellular vesicles (EVs), consisting of exosomes, micro-vesicles, and other vesicles, mainly originate from the multi-vesicular body (MVB) pathway or plasma membrane. EVs are increasingly recognized as a tool to mediate the intercellular communication and are closely related to human health. Viral infection is associated with various diseases, including respiratory diseases, neurological diseases, and cancers. Accumulating studies have shown that viruses could modulate their infection ability and pathogenicity through regulating the component and function of EVs. Non-coding RNA (ncRNA) molecules are often targets of viruses and also serve as the main functional cargo of virus-related EVs, which have an important role in the epigenetic regulation of target cells. In this review, we summarize the research progress of EVs under the regulation of viruses, highlighting the content alteration and function of virus-regulated EVs, emphasizing their isolation methods in the context of virus infection, and potential antiviral strategies based on their use. This review would promote the understanding of the viral pathogenesis and the development of antiviral research.
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影响因子：
6.4
作者：
Duette G;Pereyra Gerber P;Rubione J;Perez PS;Landay AL;Crowe SM;Liao Z;Witwer KW;Holgado MP;Salido J;Geffner J;Sued O;Palmer CS;Ostrowski M
通讯作者：
Ostrowski M
影响因子：
4.6
作者：
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影响因子：
5.2
作者：
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通讯作者：
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影响因子：
6.7
作者：
Fu Y;Zhang L;Zhang F;Tang T;Zhou Q;Feng C;Jin Y;Wu Z
通讯作者：
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影响因子：
16
作者：
Cocozza F;Névo N;Piovesana E;Lahaye X;Buchrieser J;Schwartz O;Manel N;Tkach M;Théry C;Martin-Jaular L
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