High prevalence of pre-existing serological cross-reactivity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in sub-Saharan Africa.
High prevalence of pre-existing serological cross-reactivity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in sub-Saharan Africa.
复制标题
DOI：
10.1016/j.ijid.2020.10.104
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Wood C
中科院分区：
文献类型：
--
作者：
Tso FY;Lidenge SJ;Peña PB;Clegg AA;Ngowi JR;Mwaiselage J;Ngalamika O;Julius P;West JT;Wood C
严重急性呼吸系统综合征冠状病毒-2 （SARS-CoV-2）在美国、欧洲和亚洲发生了显著的发病率和死亡率，而撒哈拉以南非洲（SSA）的感染和死亡人数仍然相对较低。据推测，在COVID-19大流行之前，SSA人群暴露于其他冠状病毒，导致对SARS-CoV-2感染和发病机制产生一定程度的交叉保护。我们通过比较从SSA和美国收集的大流行前血浆样本中的SARS-CoV-2交叉反应抗体来评估这一假设。收集来自SSA和美国的covid -19大流行前血浆样本，采用免疫荧光法检测所有已知人类冠状病毒（hcov）刺突蛋白和核衣壳蛋白。与美国相比，SSA样本中SARS-CoV-2血清学交叉反应的流行率显著高于美国。这些交叉反应样本大多数交叉识别SARS-CoV-2核衣壳蛋白和其他hcov的刺突蛋白。在大多数样本中检测到HCoV-NL63和HCoV-229E的核衣壳蛋白，从而暗示先前暴露于这两种hcov可能是针对SARS-CoV-2的交叉反应性抗体的来源。SSA中SARS-CoV-2感染和疾病的低发病率似乎与大流行前hcov的血清学交叉识别相关，hcov在SSA中比美国普遍得多。
Significant morbidity and mortality have occurred in the USA, Europe, and Asia due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), whereas the numbers of infections and deaths in sub-Saharan Africa (SSA) have remained comparatively low. It has been hypothesized that exposure of the population in SSA to other coronaviruses prior to the COVID-19 pandemic resulted in some degree of cross-protection against SARS-CoV-2 infection and pathogenesis. We evaluated this hypothesis by comparing SARS-CoV-2 cross-reactive antibodies in pre-pandemic plasma samples collected from SSA and the USA. Pre-COVID-19 pandemic plasma samples from SSA and the USA were collected and tested by immunofluorescence assay against the spike and nucleocapsid proteins of all known human coronaviruses (HCoVs). The prevalence of SARS-CoV-2 serological cross-reactivity was significantly higher in samples from SSA compared with the USA. Most of these cross-reactive samples cross-recognized the SARS-CoV-2 nucleocapsid protein and the spike proteins of other HCoVs. Nucleocapsid proteins from HCoV-NL63 and HCoV-229E were detected in most samples, thereby implicating prior exposure to these two HCoVs as the likely source of cross-reactive antibodies against SARS-CoV-2. The low incidences of SARS-CoV-2 infection and disease in SSA appear to be correlated with the pre-pandemic serological cross-recognition of HCoVs, which are substantially more prevalent in SSA than the USA.
登录
查看更多内容
影响因子：
4
作者：
Semeere A;Wenger M;Busakhala N;Buziba N;Bwana M;Muyindike W;Amerson E;Maurer T;McCalmont T;LeBoit P;Musick B;Yiannoutsos C;Lukande R;Castelnuovo B;Laker-Oketta M;Kambugu A;Glidden D;Wools-Kaloustian K;Martin J
通讯作者：
Martin J
影响因子：
4.4
作者：
Oleribe, Obinna O.;Salako, Babatunde L.;Taylor-Robinson, Simon D.
通讯作者：
Taylor-Robinson, Simon D.
影响因子：
9.4
作者：
Gaunt, E. R.;Hardie, A.;Templeton, K. E.
通讯作者：
Templeton, K. E.
影响因子：
6.4
作者：
Esper, F;Weibel, C;Kahn, JS
通讯作者：
Kahn, JS
影响因子：
28.3
作者：
Boni, Maciej F.;Lemey, Philippe;Robertson, David L.
通讯作者：
Robertson, David L.