Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial.
Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial.
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DOI：
10.1016/j.fertnstert.2013.07.1997
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发表时间：
2013-12
影响因子：
6.7
通讯作者：
Steiner, Anne Z.
中科院分区：
文献类型：
--
作者：
Findley, Austin D.;Siedhoff, Matthew T.;Hobbs, Kumari A.;Steege, John F.;Carey, Erin T.;McCall, Christina A.;Steiner, Anne Z.
研究计划保留卵巢时，腹腔镜子宫切除术中输卵管切除术对卵巢储备的短期影响，以确定大规模开展本研究的可行性。随机对照试验。三级护理，学术医疗中心。2012年4月至2012年9月，30名年龄为18至45岁的绝经前女性因良性适应症接受了保留卵巢的腹腔镜子宫切除术。在保留卵巢的腹腔镜子宫切除术时双侧输卵管切除术（n=15）与无输卵管切除术（n=15）。术前、术后4-6周和术后3个月测量抗苗勒管激素（AMH）。从病历中提取手术时间和估计失血量。平均AMH水平在基线（2.26 vs. 2.25ng/ml）、术后4-6周（1.03 vs. 1.25ng/ml）或术后3个月（1.86 vs. 1.82ng/ml）时，输卵管切除术与未输卵管切除术的女性之间无显著差异。两组之间的平均AMH水平从基线到术后3个月也没有显著的时间变化（-0.07 vs-0.08ng/ml）。手术时间（116 vs. 115 min）或估计失血量（70 vs. 91 ml）无差异。在腹腔镜子宫切除术保留卵巢的同时进行输卵管切除术是一种安全的手术，对卵巢储备没有任何短期的有害影响，如AMH水平所测量的。进行这种性质的试验是可行的，具有足够的效力和长期随访，需要明确证实这些结果。
To examine the short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve when ovarian preservation is planned in order to determine the feasibility of conducting this study on a large scale. Pilot Randomized controlled trial. Tertiary care, academic medical center. Thirty premenopausal women aged 18 to 45 years underwent laparoscopic hysterectomy with ovarian preservation for benign indications from April 2012 to September 2012. Bilateral salpingectomy (n=15) versus no salpingectomy (n=15) at the time of laparoscopic hysterectomy with ovarian preservation. Antimüllerian hormone (AMH) was measured preoperatively, 4–6 weeks postoperatively, and 3 months postoperatively. Operative time and estimated blood loss were abstracted from the medical record. Mean AMH levels were not significantly different at baseline (2.26 vs. 2.25ng/ml), 4–6 weeks postoperatively (1.03 vs. 1.25ng/ml), or 3 months postoperatively (1.86 vs. 1.82ng/ml) among women with salpingectomy versus no salpingectomy, respectively. There was also no significant temporal change in mean AMH level from baseline to 3 months postoperatively (−.07 vs. −.08ng/ml) between groups. No difference in operative time (116 vs. 115min) or estimated blood loss (70 vs. 91ml) was observed. Salpingectomy at the time of laparoscopic hysterectomy with ovarian preservation is a safe procedure that does not appear to have any short-term deleterious effects on ovarian reserve, as measured by AMH level. Conducting a trial of this nature that is adequately powered with long-term follow-up would be feasible and is required to definitively confirm these results.
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影响因子：
120.7
作者：
Wright, Jason D.;Ananth, Cande V.;Hershman, Dawn L.
通讯作者：
Hershman, Dawn L.
DOI：
10.1097/gme.0b013e318205e2ac
发表时间：
2011-07-01
影响因子：
2.7
作者：
Tehrani, Fahimeh Ramezani;Shakeri, Nezhat;Azizi, Fereidoun
通讯作者：
Azizi, Fereidoun
DOI：
10.1111/j.1447-0756.2007.00669.x
发表时间：
2007-12-01
影响因子：
1.6
作者：
Sezik, Mekin;Ozkaya, Okan;Kaya, Hakan
通讯作者：
Kaya, Hakan
影响因子：
6.7
作者：
de Vet, A;Laven, JSE;Fauser, BCJM
通讯作者：
Fauser, BCJM
影响因子：
4.7
作者：
Morelli, Michele;Venturella, Roberta;Zullo, Fulvio
通讯作者：
Zullo, Fulvio