Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain.
Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain.
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瞬时受体电位（TRP）离子通道在口面部疼痛。
DOI：
10.1007/s12035-021-02284-2
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发表时间：
2021-06
影响因子：
5.1
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Luo Y;Suttle A;Zhang Q;Wang P;Chen Y
口面疼痛，包括颞下颌关节紊乱病疼痛、三叉神经痛、牙痛和使人衰弱的头痛，每年影响数百万美国人，具有显著的人口健康影响。尽管存在大量的信息对这个问题，口面疼痛的分子基础仍然难以捉摸。二十年的研究已经确定瞬时受体电位（TRP）离子通道在病理性疼痛中起着至关重要的作用。TRP离子通道在三叉神经感觉系统中有明确的表达，在口面部疼痛的传导和发病机制中具有重要的作用。虽然有许多相似之处，口面感觉系统显示出一些不同的外周和中枢疼痛处理和不同的敏感性从脊髓感觉系统。相对于脊髓介导疼痛中TRP的广泛综述，三叉神经介导疼痛中TRP的总结尚未得到充分记录。本文综述了TRP离子通道，特别是TRPV1，TRPA1，TRPV4和TRPM8在口面疼痛中的作用，并讨论了其可能的细胞和分子机制。
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of Americans each year with significant population health impact. Despite the existence of a large body of information on the subject, the molecular underpinnings of orofacial pain remain elusive. Two decades of research has identified that transient receptor potential (TRP) ion channels play a crucial role in pathological pain. A number of TRP ion channels are clearly expressed in the trigeminal sensory system and have critical functions in the transduction and pathogenesis of orofacial pain. Although there are many similarities, the orofacial sensory system shows some distinct peripheral and central pain processing and different sensitivities from the spinal sensory system. Relative to the extensive review on TRPs in spinally-mediated pain, the summary of TRPs in trigeminally-mediated pain has not been well-documented. This review focuses on the current experimental evidence involving TRP ion channels, particularly TRPV1, TRPA1, TRPV4, and TRPM8 in orofacial pain and discusses their possible cellular and molecular mechanisms.
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影响因子：
3.3
作者：
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