TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain.
TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain.
复制标题
DOI：
10.3389/fmolb.2018.00073
复制
发表时间：
2018
影响因子：
5
通讯作者：
Ferrer-Montiel A
中科院分区：
文献类型：
--
作者：
Artero-Morales M;González-Rodríguez S;Ferrer-Montiel A
慢性疼痛是最使人衰弱的人类疾病之一，对我们的社会来说是一种社会和经济负担。人们正在努力了解疼痛传导的病理生理学基础的分子和细胞机制。特别值得注意的是，某些类型的慢性疼痛，如偏头痛，显示出显着的性别二型性，在女性中的患病率是男性的三倍。偏头痛的性别患病率似乎与性腺和遗传因素引起的性别差异有关。事实上，躯体感觉、免疫和内皮系统的功能似乎受到性激素以及发育过程中差异表达的X连锁基因的调节。在这里，我们回顾了目前的数据调制的躯体感觉系统功能的性腺激素。虽然这仍然是一个需要深入研究的领域，但有证据表明性激素在转录、翻译和功能水平上直接调节伤害感受器的活性。性激素对TRP通道（如TRPV 1）的影响正在积累数据，TRPV 1对偏头痛和其他慢性疼痛综合征中的伤害感受器兴奋性和致敏性做出关键贡献。这些数据表明，性腺激素对TRP通道表达和/或活性的调节为药物干预提供了新的途径，这可能有助于靶向在偏头痛中观察到的性别二型性。
Chronic pain is one of the most debilitating human diseases and represents a social and economic burden for our society. Great efforts are being made to understand the molecular and cellular mechanisms underlying the pathophysiology of pain transduction. It is particularly noteworthy that some types of chronic pain, such as migraine, display a remarkable sex dimorphism, being up to three times more prevalent in women than in men. This gender prevalence in migraine appears to be related to sex differences arising from both gonadal and genetic factors. Indeed, the functionality of the somatosensory, immune, and endothelial systems seems modulated by sex hormones, as well as by X-linked genes differentially expressed during development. Here, we review the current data on the modulation of the somatosensory system functionality by gonadal hormones. Although this is still an area that requires intense investigation, there is evidence suggesting a direct regulation of nociceptor activity by sex hormones at the transcriptional, translational, and functional levels. Data are being accumulated on the effect of sex hormones on TRP channels such as TRPV1 that make pivotal contributions to nociceptor excitability and sensitization in migraine and other chronic pain syndromes. These data suggest that modulation of TRP channels' expression and/or activity by gonadal hormones provide novel pathways for drug intervention that may be useful for targeting the sex dimorphism observed in migraine.
登录
查看更多内容
DOI：
10.1002/ajmg.b.32007
发表时间：
2012-01-01
影响因子：
2.8
作者：
Carreno, Oriel;Corominas, Roser;Macaya, Alfons
通讯作者：
Macaya, Alfons
睾酮对口面部肌炎疼痛模型大鼠TRPV1表达的影响
影响因子：
3.1
作者：
Bai, Xiaofeng;Zhang, Xia;Zhou, Qing
通讯作者：
Zhou, Qing
影响因子：
4.8
作者：
Belugin, Sergei;Diogenes, Anibal R.;Akopian, Armen N.
通讯作者：
Akopian, Armen N.
影响因子：
2.7
作者：
Bennett, HL;Gustafsson, JÅ;Keast, JR
通讯作者：
Keast, JR
影响因子：
4.9
作者：
Bolay, Hayrunnisa;Ozge, Aynur;Ozturk, Musa
通讯作者：
Ozturk, Musa