Chemokine blockade: a new era in the treatment of rheumatoid arthritis?

Chemokine blockade: a new era in the treatment of rheumatoid arthritis?
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DOI:
10.1186/ar1172
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发表时间:
2004
影响因子:
4.9
通讯作者:
Tak PP
Tak PP
中科院分区:
医学2区
文献类型:
--
作者:
Haringman JJ;Tak PP

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趋化因子或趋化因子受体的阻断正在成为各种免疫介导病症的新的潜在治疗方法。本文综述了基于动物模型和患者研究的类风湿性关节炎的治疗潜力。几个敲除模型以及在体内使用的趋化因子拮抗剂进行了讨论。这些数据的审查表明,这种方法可能会导致新的治疗策略,类风湿性关节炎和其他慢性炎症性疾病。
Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of chemokine antagonists are discussed. Review of these data suggests that this approach might lead to novel therapeutic strategies in rheumatoid arthritis and other chronic inflammatory disorders.
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