Incidence and prevalence of juvenile idiopathic arthritis in the United Kingdom, 2000-2018: results from the Clinical Practice Research Datalink.
Incidence and prevalence of juvenile idiopathic arthritis in the United Kingdom, 2000-2018: results from the Clinical Practice Research Datalink.
复制标题
DOI：
10.1093/rheumatology/keab714
复制
发表时间：
2022-05-30
期刊：
影响因子：
5.5
通讯作者：
Humphreys, Jenny
中科院分区：
文献类型：
--
作者：
Costello, Ruth;McDonagh, Janet;Hyrich, Kimme;Humphreys, Jenny
关键词：
JIA的发病率和患病率最后一次在英国估计是在1994年。从那时起，这种疾病被重新分类，儿科风湿病学的专业已经发展，并且随着新的先进疗法的出现，疾病管理发生了重大转变。这项研究的目的是提供最新的国家估计这种疾病。临床实践研究数据链（CPRD）GOLD和Aurum数据库中确定了患有JIA的儿童和年轻人（JIA），这些数据来自英国两个最常用的初级保健电子健康记录系统。将这些数据库合并，并使用预定义的代码列表确定队列（2000-18）。通过与英格兰医院事件统计数据的链接进行验证。计算年发病率和患病率，并按性别、年龄组和英国国家分层。对英国人群进行了直接标准化，并计算了2003年至2018年的5年发病率。按每十万人口计算的年标准化发病率为5.61。2018年的年龄标准化患病率为每10万人43.5人。苏格兰的发病率高于英格兰：发病率比为1.27（95% CI 1.11，1.46）。5年发病率随时间推移无显著变化。这项研究提供了25年来英国JIA发生的第一个同期估计。这些数据提供了重要的估计，为JIA的管理提供资源分配和卫生服务发展的信息。
The incidence and prevalence of JIA was last estimated in the UK in 1994. Since then the disease has been reclassified, the specialty of paediatric rheumatology has evolved and there has been a significant shift in disease management with new advanced therapies. This study aimed to provide up-to-date national estimates of this disease. Children and young people (CYP) with JIA were identified in the Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases, which source data from the two most commonly used primary care electronic health record systems in the UK. These databases were combined and the cohort was identified (2000–18) using predefined code lists. Validation was performed through linkage to the England Hospital Episode Statistics. Annual incidence and prevalence rates were calculated and stratified by gender, age group and nation of the UK. Direct standardization to the UK population was performed and 5 year incidence rates were calculated between 2003 and 2018. The age-standardized incidence rate was 5.61 per 100 000 population. The age-standardized prevalence rate in 2018 was 43.5 per 100 000. Rates were higher in Scotland compared with England: incidence rate ratio 1.27 (95% CI 1.11, 1.46). The 5 year incidence rates did not change significantly over time. This study has provided the first contemporaneous estimates of occurrence of JIA in the UK in 25 years. These data provide important estimates to inform resource allocation and health service development for management of JIA.
登录
查看更多内容
影响因子：
13.3
作者：
Krause, Megan L.;Crowson, Cynthia S.;Michet, C. John;Mason, Thomas;Muskardin, Theresa Wampler;Matteson, Eric L.
通讯作者：
Matteson, Eric L.
影响因子：
5.5
作者：
Abhishek, Abhishek;Doherty, Michael;Grainge, Matthew J.
通讯作者：
Grainge, Matthew J.
影响因子：
4.7
作者：
Shiff, Natalie J.;Oen, Kiem;Lix, Lisa M.
通讯作者：
Lix, Lisa M.
影响因子：
7.7
作者：
Wolf, Achim;Dedman, Daniel;Myles, Puja
通讯作者：
Myles, Puja
影响因子：
7.7
作者：
Herrett E;Gallagher AM;Bhaskaran K;Forbes H;Mathur R;van Staa T;Smeeth L
通讯作者：
Smeeth L