How and when the fMRI BOLD signal relates to underlying neural activity: the danger in dissociation.
How and when the fMRI BOLD signal relates to underlying neural activity: the danger in dissociation.
复制标题
DOI：
10.1016/j.brainresrev.2009.12.004
复制
发表时间：
2010-03
影响因子：
--
通讯作者：
Ekstrom A
中科院分区：
文献类型：
--
作者：
Ekstrom A
功能磁共振成像（fMRI）已成为测量人脑中与行为相关的神经活动的主要手段。然而，血氧水平依赖性（BOLD）信号与潜在神经活动之间的关系仍然是一个悬而未决且正在积极研究的问题。为感觉新皮层建立的一个广泛接受的模型表明，BOLD 信号以局部场电位的形式反映突触周围的活动，而不是单个神经元的尖峰率。然而，最近的一些实验结果表明，BOLD、尖峰和局部场电位分离的情况。根据解释这种分离的文献，讨论了两种不同的模型，即基于电路和基于血管的解释。发现这两种模型都可以解释某些测试情况下和某些大脑区域的现有数据。由于基于血管和局部电路的解释都对 BOLD-LFP 耦合模型提出了挑战，因此这些模型为预测何时可以预期 BOLD 反映神经处理以及何时与 BOLD 的潜在关系可能比直接对应关系更复杂提供了指导。
Functional magnetic resonance imaging (fMRI) has become the dominant means of measuring behavior-related neural activity in the human brain. Yet the relation between the blood oxygen-level dependent (BOLD) signal and underlying neural activity remains an open and actively researched question. A widely accepted model, established for sensory neo-cortex, suggests that the BOLD signal reflects peri-synaptic activity in the form of the local field potential rather than the spiking rate of individual neurons. Several recent experimental results, however, suggest situations in which BOLD, spiking, and the local field potential dissociate. Two different models are discussed, based on the literature reviewed to account for this dissociation, a circuitry-based and vascular-based explanation. Both models are found to account for existing data under some testing situations and in certain brain regions. Because both the vascular and local circuitry-based explanations challenge the BOLD-LFP coupling model, these models provide guidance in predicting when BOLD can be expected to reflect neural processing and when the underlying relation with BOLD may be more complex than a direct correspondence.
登录
查看更多内容
影响因子：
5.3
作者：
Axmacher, Nikolai;Mormann, Florian;Fell, Juergen
通讯作者：
Fell, Juergen
影响因子：
14.5
作者：
FLETCHER, PC;FRITH, CD;DOLAN, RJ
通讯作者：
DOLAN, RJ
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
2.5
作者：
BOROWSKY, IW;COLLINS, RC
通讯作者：
COLLINS, RC
影响因子：
5.8
作者：
Bookheimer, Susan
通讯作者：
Bookheimer, Susan