Long Noncoding RNAs in Atherosclerosis: JACC Review Topic of the Week.
Long Noncoding RNAs in Atherosclerosis: JACC Review Topic of the Week.
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DOI：
10.1016/j.jacc.2018.08.2161
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发表时间：
2018-11-06
影响因子：
24
通讯作者：
Sallam T
中科院分区：
文献类型：
--
作者：
Zhang Z;Salisbury D;Sallam T
动脉粥样硬化是一种复杂的慢性疾病，其特征是血管壁中的脂质沉积，导致涉及平滑肌、内皮和免疫细胞的炎症和增殖级联反应。尽管我们对动脉粥样硬化机制和心血管死亡率总体降低的理解有了很大的进步，但绝对疾病负担仍然很高。最近发现的一组称为长非编码 RNA (lncRNA) 的新介质为开发动脉粥样硬化血栓性疾病的新型诊断和治疗工具提供了独特的机会。许多研究表明，lncRNA 是健康和疾病的重要介质，并且迅速积累的证据表明 lncRNA 参与控制动脉粥样硬化的调节回路。在这篇综述中，我们概述了 lncRNA 对动脉粥样硬化及其相关危险因素（包括高胆固醇血症、糖尿病、高血压和肥胖）的重要贡献。动脉粥样硬化是全球死亡的最具破坏性的原因，也是减轻心血管疾病的重大努力的中心。了解基因序列如何控制功能大大提高了我们对包括动脉粥样硬化在内的常见心血管问题的理解。在人类基因组计划证据的推动下，基因目录的扩展导致了生物学中新成员的发现，即长非编码 RNA (lncRNA)。在这篇综述中，我们讨论了 lncRNA 对动脉粥样硬化危险因素和参与斑块形成的关键细胞的贡献。 lncRNA 的鉴定为缓解心血管风险提供了新的认识机会。
Atherosclerosis is a complex and chronic disease characterized by lipid deposition in the vessel wall that leads to an inflammatory and proliferative cascade involving smooth muscle, endothelial and immune cells. Despite substantial improvements in our understanding of mechanisms contributing to atherosclerosis and overall reduction in cardiovascular mortality, the absolute disease burden remains substantially high. The recent discovery of a new group of mediators known as long noncoding RNAs (lncRNAs) offers a unique opportunity for the development of novel diagnostic and therapeutic tools in atherothrombotic disease. A number of studies suggest that lncRNAs are important mediators in health and disease and rapidly accumulating evidence implicates lncRNAs in regulatory circuits controlling atherosclerosis. In this review, we outline important contributions of lncRNAs to atherosclerosis and its associated risk factors including hypercholesterolemia, diabetes, hypertension and obesity. Atherosclerosis is the single most devastating cause of worldwide mortality forming the epicenter of major efforts to mitigate cardiovascular disease. Understanding how genetic sequences control function has substantially improved our understanding of common cardiovascular problems including atherosclerosis. Galvanized by evidence from the human genome project, an expanded genetic catalog has led to the discovery of new players in biology known as long noncoding RNAs (lncRNAs). In this review, we discuss the contributions of lncRNAs to atherosclerosis risk factors and key cells involved in plaque formation. The identification of lncRNAs offers newly recognized opportunities for cardiovascular risk mitigation.
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影响因子：
10.5
作者：
Arnes L;Akerman I;Balderes DA;Ferrer J;Sussel L
通讯作者：
Sussel L
影响因子：
3.7
作者：
Işın M;Uysaler E;Özgür E;Köseoğlu H;Şanlı Ö;Yücel ÖB;Gezer U;Dalay N
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Dalay N
影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
影响因子：
29
作者：
Akerman I;Tu Z;Beucher A;Rolando DMY;Sauty-Colace C;Benazra M;Nakic N;Yang J;Wang H;Pasquali L;Moran I;Garcia-Hurtado J;Castro N;Gonzalez-Franco R;Stewart AF;Bonner C;Piemonti L;Berney T;Groop L;Kerr-Conte J;Pattou F;Argmann C;Schadt E;Ravassard P;Ferrer J
通讯作者：
Ferrer J
DOI：
10.1161/atvbaha.114.303240
发表时间：
2014-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Bell RD;Long X;Lin M;Bergmann JH;Nanda V;Cowan SL;Zhou Q;Han Y;Spector DL;Zheng D;Miano JM
通讯作者：
Miano JM