Endoderm generates endothelial cells during liver development.
Endoderm generates endothelial cells during liver development.
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DOI：
10.1016/j.stemcr.2014.08.009
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发表时间：
2014-10-14
影响因子：
5.9
通讯作者：
Gouon-Evans, Valerie
中科院分区：
文献类型：
--
作者：
Goldman, Orit;Han, Songyan;Hamou, Wissam;de Villeroche, Vanina Jodon;Uzan, Georges;Lickert, Heiko;Gouon-Evans, Valerie
Organogenesis requires expansion of the embryonic vascular plexus that migrates into developing organs through a process called angiogenesis. Mesodermal progenitors are thought to derive endothelial cells (ECs) that contribute to both embryonic vasculogenesis and the subsequent organ angiogenesis. Here, we demonstrate that during development of the liver, which is an endoderm derivative, a subset of ECs is generated from FOXA2+ endoderm-derived fetal hepatoblast progenitor cells expressing KDR (VEGFR2/FLK-1). Using human and mouse embryonic stem cell models, we demonstrate that KDR+FOXA2+ endoderm cells developing in hepatic differentiation cultures generate functional ECs. This introduces the concept that ECs originate not exclusively from mesoderm but also from endoderm, supported in Foxa2 lineage-tracing mouse embryos by the identification of FOXA2+ cell-derived CD31+ ECs that integrate the vascular network of developing fetal livers. Functional ECs are generated from human ESC-derived KDR+ endoderm cells Functional ECs are generated from mouse ESC-derived KDR+FOXA2+ endoderm cells FOXA2+ endoderm cells contribute in vivo to a subset of ECs in the mouse fetal liver In this article, Gouon-Evans and colleagues show that endoderm generates a subset of endothelial cells in the developing liver. The endoderm-derived endothelial cells develop from a hepatic progenitor expressing the VEGF receptor (KDR) in mouse and human embryonic stem cell hepatic differentiation cultures. These bipotential progenitors were confirmed in the developing liver using endoderm lineage-tracing mouse models.
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DOI：
10.1002/ar.20710
发表时间：
2008-06-01
影响因子：
2
作者：
Roskams, T.;Desmet, V.
通讯作者：
Desmet, V.
DOI：
10.1073/pnas.1203605109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Horn, Signe;Kobberup, Sune;Jensen, Jan N.
通讯作者：
Jensen, Jan N.
影响因子：
46.9
作者：
Gouon-Evans, Valerie;Boussemart, Lise;Keller, Gordon
通讯作者：
Keller, Gordon
影响因子：
2.5
作者：
Nonaka, Hidenori;Tanaka, Minoru;Miyajima, Atsushi
通讯作者：
Miyajima, Atsushi
影响因子：
5.2
作者：
Goldman, Orit;Feraud, Olivier;Uzan, Georges
通讯作者：
Uzan, Georges