Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination.
Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination.
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DOI：
10.1038/s41467-021-25035-2
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发表时间：
2021-08-06
影响因子：
16.6
通讯作者：
Bergles DE
中科院分区：
文献类型：
--
作者：
Call CL;Bergles DE
大脑皮层轴突显示髓鞘覆盖范围广。少突胶质细胞通过选择一组轴突进行髓鞘形成来建立这种模式；然而，髓磷脂在不同神经元上的分布和脱髓鞘后节间置换的程度仍有待确定。在这里，我们表明在体感觉皮层中七种不同的神经元亚型的髓鞘形成模式受到轴突直径和神经元身份的影响。不同髓鞘密度的皮质区域保留了小白蛋白中间神经元对髓鞘形成的偏好，这表明髓鞘丰度的区域差异是通过局部控制少突胶质形成引起的。通过体内髓鞘的成像损失和再生，我们发现髓鞘在单个轴突上的分布被改变，但不同神经元亚型的总体髓鞘含量得到恢复。我们的研究结果表明，髓鞘形成的局部变化是可容忍的，允许再生的少突胶质细胞通过轴突的机会性选择来恢复不同神经元上的髓鞘含量。灰质中不同神经元的髓鞘形成模式尚未完全确定。在这里，作者表明轴突直径和神经元身份影响完整小鼠体感觉皮层的髓鞘形成模式。体内成像显示，髓鞘再生改变了髓鞘模式，但恢复了不同神经元亚型的总体髓鞘含量。
Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes establish this pattern by selecting a cohort of axons for myelination; however, the distribution of myelin on distinct neurons and extent of internode replacement after demyelination remain to be defined. Here we show that myelination patterns of seven distinct neuron subtypes in somatosensory cortex are influenced by both axon diameter and neuronal identity. Preference for myelination of parvalbumin interneurons was preserved between cortical areas with varying myelin density, suggesting that regional differences in myelin abundance arises through local control of oligodendrogenesis. By imaging loss and regeneration of myelin sheaths in vivo we show that myelin distribution on individual axons was altered but overall myelin content on distinct neuron subtypes was restored. Our findings suggest that local changes in myelination are tolerated, allowing regenerated oligodendrocytes to restore myelin content on distinct neurons through opportunistic selection of axons. Myelination patterns of different neurons in grey matter have not been fully defined. Here, the authors show that axon diameter and neuronal identity influence myelination patterns in the intact mouse somatosensory cortex. In vivo imaging revealed that remyelination altered myelin patterns but restored overall myelin content on distinct neuron subtypes.
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影响因子：
25
作者：
Hughes EG;Orthmann-Murphy JL;Langseth AJ;Bergles DE
通讯作者：
Bergles DE
DOI：
10.1073/pnas.1811013115
发表时间：
2018-11-13
影响因子：
11.1
作者：
Dutta DJ;Woo DH;Lee PR;Pajevic S;Bukalo O;Huffman WC;Wake H;Basser PJ;SheikhBahaei S;Lazarevic V;Smith JC;Fields RD
通讯作者：
Fields RD
影响因子：
5.3
作者：
Almeida RG
通讯作者：
Almeida RG
影响因子：
16.2
作者：
Brinkmann, Bastian G.;Agarwal, Amit;Sereda, Michael W.;Garratt, Alistair N.;Mueller, Thomas;Wende, Hagen;Stassart, Ruth M.;Nawaz, Schanila;Humml, Christian;Velanac, Viktorija;Radyushkin, Konstantin;Goebbels, Sandra;Fischer, Tobias M.;Franklin, Robin J.;Lai, Cary;Ehrenreich, Hannelore;Birchmeier, Carmen;Schwab, Markus H.;Nave, Klaus Armin
通讯作者：
Nave, Klaus Armin
影响因子：
11.2
作者：
Chang, Ansi;Staugaitis, Susan M.;Dutta, Ranjan;Batt, Courtney E.;Easley, Kathryn E.;Chomyk, Anthony M.;Yong, V. Wee;Fox, Robert J.;Kidd, Grahame J.;Trapp, Bruce D.
通讯作者：
Trapp, Bruce D.