Relationship between high dose intake of vitamin B12 and glaucoma: Evidence from NHANES 2005-2008 among United States adults.
Relationship between high dose intake of vitamin B12 and glaucoma: Evidence from NHANES 2005-2008 among United States adults.
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DOI：
10.3389/fnut.2023.1130032
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发表时间：
2023
影响因子：
5
通讯作者：
Yu, Ziyan
中科院分区：
文献类型：
--
作者：
Liu, Zhongwei;Hu, Yi;Wang, Yuhan;Xu, Baiwei;Zhao, Jiangyue;Yu, Ziyan
关键词：
青光眼目前已成为世界第二大致盲原因。血清维生素B12水平与青光眼的发生发展密切相关。我们进行了这项研究，以证实这种联系。这项横断面研究包括2005至2008年间全国健康和营养检查调查(NHANES)中年龄在40岁及以上的594名参与者。使用眼科数字成像系统(视网膜造影术)进行视网膜成像，以评估视网膜是否存在青光眼病变的特征。采用Logistic回归模型评估膳食维生素摄入量与青光眼的关系。经过筛选，最终纳入594名受试者。在所有维生素摄入量中，我们观察到两组之间维生素B12摄入量的显著差异(5.93vs.4.77 mg，p = 0.033)。Logistic回归分析结果显示，维生素B12摄入与青光眼发病呈显著正相关(模型1：OR = 1.078，95%CI = 1.019~1.141；模型2：OR = 1.092，95%CI = 1.031~1.158；模型3：OR = 1.092，95%CI = 1.029~1.158)。在进行分位数回归后，我们在第四个四分位数(模型1：OR = 1.133，95%CI = 1.060-1.210；模型2：OR = 1.141，95%CI = 1.072-1.215；模型3：OR = 1.146，95%CI = 1.071-1.226)中观察到维生素B12摄入量与青光眼发病率呈显著正相关。因此，上述结果表明，大剂量摄入维生素B12可能促进青光眼的发展。
Glaucoma has currently become the second leading cause of blindness in the world. Serum vitamin B12 level has been found to be involved in the development and progression of glaucoma. We performed the present study to confirm this association. This cross-sectional study included 594 participants aged 40 years and older in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. Retinal imaging was performed using the Ophthalmic Digital Imaging system (Retinography) to assess the retina for the presence of features of glaucomatous lesions. Logistic regression models were used to assess the association between dietary vitamin intake and glaucoma. After screening, 594 subjects were finally included. Among all vitamin intakes, we observed significant differences between the two groups for vitamin B12 intake (5.93 vs. 4.77 mg, p = 0.033). According to the logistic regression results, the intake of vitamin B12 was significantly positively associated with glaucoma (model 1: OR = 1.078, 95% CI = 1.019–1.141; model 2: OR = 1.092, 95% CI = 1.031–1.158; model 3: OR = 1.092, 95% CI = 1.029–1.158). After performing a quantile regression, we observed a significant positive association between vitamin B12 intake and incident glaucoma in the fourth quartile (model 1: OR = 1.133, 95% CI = 1.060–1.210; model 2: OR = 1.141, 95% CI = 1.072–1.215; model 3: OR = 1.146, 95% CI = 1.071–1.226). Therefore, the above results, high-dose intake of vitamin B12 may promote the development of glaucoma.
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