Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals.
Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals.
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DOI：
10.1016/j.vaccine.2013.12.009
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发表时间：
2014-02-07
期刊：
影响因子：
5.5
通讯作者：
Poland, Gregory A.
中科院分区：
文献类型：
--
作者：
Oysyannikova, Inna G.;White, Sarah J.;Larrabee, Beth R.;Grill, Diane E.;Jacobson, Robert M.;Poland, Gregory A.
肥胖是复杂甲型H1N1流感疾病和疫苗免疫原性差的危险因素。瘦素是一种脂肪细胞衍生的激素/细胞因子，具有许多免疫调节功能，因此可以解释对感染的易感性和不良的疫苗效果。我们招募了159名健康成人（5074岁），他们接种了含有A/California/7/2009/H1N1病毒的灭活TIV流感疫苗- ne。我们发现瘦素浓度与BMI之间存在很强的相关性（r=0.55, p<0.0001），但与血凝抗体抑制（HAI）、B细胞或颗粒酶B反应无关。我们发现瘦素浓度与免疫衰老标志物（TREC: t细胞受体切除圈）水平有轻微的相关性（r=0.23, p=0.01）。我们发现与瘦素水平相关的LEP/LEPR/GHRL基因中有8个snp，与外周血TREC水平相关的PTPN1/LEPR/STAT3基因中有4个snp （p<0.05）。PTPN1基因同义变体rs2230604的杂合性与纯合主变体相比，TREC水平显著降低（531 vs. 259, p = 0.005）。我们还发现了与流感特异性HAI和b细胞反应变异相关的LEP/ ppar /CRP基因中的8个snp （p<0.05）。我们的研究结果表明，瘦素相关基因的特定等位基因变异可能影响流感疫苗的适应性免疫反应。
Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity. Leptin, an adipocyte-derived hormone/cytokine, has many immune regulatory functions and therefore could explain susceptibility to infections and poor vaccine outcomes. We recruited 159 healthy adults (5074 years old) who were immunized with inactivated TIV influenza vacci–ne that contained A/California/7/2009/H1N1 virus. We found a strong correlation between leptin concentration and BMI (r=0.55, p<0.0001), but no association with hemagglutination antibody inhibition (HAI), B-cell, or granzyme B responses. We found a slight correlation between leptin concentration and an immunosenescence marker (TREC: T-cell receptor excision circles) level (r=0.23, p=0.01). We found eight SNPs in the LEP/LEPR/GHRL genes that were associated with leptin levels and four SNPs in the PTPN1/LEPR/STAT3 genes associated with peripheral blood TREC levels (p<0.05). Heterozygosity of the synonymous variant rs2230604 in the PTPN1 gene was associated with a significantly lower (531 vs. 259, p = 0.005) TREC level, as compared to the homozygous major variant. We also found eight SNPs in the LEP/PPARG/CRP genes associated with variations in influenza-specific HAI and B-cell responses (p<0.05). Our results suggest that specific allelic variations in the leptin-related genes may influence adaptive immune responses to influenza vaccine.
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影响因子：
4.6
作者：
Fernández-Riejos P;Najib S;Santos-Alvarez J;Martín-Romero C;Pérez-Pérez A;González-Yanes C;Sánchez-Margalet V
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3.7
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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