Modulating excitation through plasticity at inhibitory synapses.
Modulating excitation through plasticity at inhibitory synapses.
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DOI：
10.3389/fncel.2014.00093
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发表时间：
2014
影响因子：
5.3
通讯作者：
Piskorowski R
中科院分区：
文献类型：
--
作者：
Chevaleyre V;Piskorowski R
学习被认为依赖于突触功效的持久变化，如长时程增强和长时程抑制。因此，大量的研究试图阐明这些形式的可塑性背后的机制。传统上，兴奋性突触的经验依赖性变化被认为是学习和记忆形成的基础。然而，随着近年来对抑制性传递的研究，抑制性突触不仅具有可塑性，而且还提供了一种调节兴奋性传递和诱导兴奋性突触可塑性的额外途径。由于最近的技术进步，在理解特定中间神经元亚型的突触传递和可塑性方面取得了进展。在这篇综述文章中，我们将描述各种形式的突触可塑性，已被归因于两个相当好的特点群体的中间神经元在海马，那些表达胆囊收缩素（CCK）和小清蛋白（PV）。我们将讨论作为抑制性传递的调制的结果，在局部回路中发生的兴奋性传递的强度和可塑性的变化。我们将重点放在海马体，因为这个区域有一个相对较好的理解电路，许多形式的活动依赖性可塑性和众多的识别中间神经元亚类。
Learning is believed to depend on lasting changes in synaptic efficacy such as long-term potentiation and long-term depression. As a result, a profusion of studies has tried to elucidate the mechanisms underlying these forms of plasticity. Traditionally, experience-dependent changes at excitatory synapses were assumed to underlie learning and memory formation. However, with the relatively more recent investigation of inhibitory transmission, it had become evident that inhibitory synapses are not only plastic, but also provide an additional way to modulate excitatory transmission and the induction of plasticity at excitatory synapses. Thanks to recent technological advances, progress has been made in understanding synaptic transmission and plasticity from particular interneuron subtypes. In this review article, we will describe various forms of synaptic plasticity that have been ascribed to two fairly well characterized populations of interneurons in the hippocampus, those expressing cholecystokinin (CCK) and parvalbumin (PV). We will discuss the resulting changes in the strength and plasticity of excitatory transmission that occur in the local circuit as a result of the modulation of inhibitory transmission. We will focus on the hippocampus because this region has a relatively well-understood circuitry, numerous forms of activity-dependent plasticity and a multitude of identified interneuron subclasses.
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影响因子：
16.2
作者：
Chevaleyre V;Siegelbaum SA
通讯作者：
Siegelbaum SA
影响因子：
25
作者：
Klausberger, T;Márton, LF;Somogyi, P
通讯作者：
Somogyi, P
DOI：
10.1073/pnas.1010669107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Chen, Yong-Jun;Zhang, Meng;Gao, Tian-Ming
通讯作者：
Gao, Tian-Ming
影响因子：
4.7
作者：
Karson, Miranda A.;Whittington, Kevin C.;Alger, Bradley E.
通讯作者：
Alger, Bradley E.
影响因子：
25
作者：
Carlson, G;Wang, Y;Alger, BE
通讯作者：
Alger, BE