Animal models of stroke.
Animal models of stroke.
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DOI：
10.1002/ame2.12179
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发表时间：
2021-09
影响因子：
3.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Li Y;Zhang J
中风是一种发病率和死亡率都很高的毁灭性疾病。动物模型是模拟中风过程不可或缺的工具，可用于研究发病机制和开发新的治疗方案。作为一种具有复杂病理生理机制的异质性疾病，在一个动物模型中模拟人类中风的所有方面是不可能的。每种模式都有独特的优势和劣势。在模拟人类缺血性卒中时，最常用的模型有短暂性或永久性线栓模型、大脑中动脉闭塞(MCAO)模型和血栓栓塞剂模型。血管内微丝闭塞模型操作简单，再灌流准确可控，适合于研究局灶性脑缺血再灌注损伤的发病机制。虽然栓塞剂模型的重复性较差，但对溶栓的研究更为方便。大鼠是中风最常用的动物模型。本文主要概述了大鼠卒中模型，并对其优缺点进行了详细的讨论。
Stroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be used for investigating mechanisms and developing novel therapeutic regimens. As a heterogeneous disease with complex pathophysiology, mimicking all aspects of human stroke in one animal model is impossible. Each model has unique strengths and weaknesses. Models such as transient or permanent intraluminal thread occlusion middle cerebral artery occlusion (MCAo) models and thromboembolic models are the most commonly used in simulating human ischemic stroke. The endovascular filament occlusion model is characterized by easy manipulation and accurately controllable reperfusion and is suitable for studying the pathogenesis of focal ischemic stroke and reperfusion injury. Although the reproducibility of the embolic model is poor, it is more convenient for investigating thrombolysis. Rats are the most frequently used animal model for stroke. This review mainly outlines the stroke models of rats and discusses their strengths and shortcomings in detail.
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