"Loser" or "Popular"?: Neural response to social status words in adolescents with major depressive disorder.
"Loser" or "Popular"?: Neural response to social status words in adolescents with major depressive disorder.
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“失败者”或“流行”？：对重度抑郁症的青少年中社会地位词的神经反应。
DOI：
10.1016/j.dcn.2017.09.005
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发表时间：
2017-12
影响因子：
4.7
通讯作者：
Ladouceur CD
中科院分区：
文献类型：
--
作者：
Silk JS;Lee KH;Kerestes R;Griffith JM;Dahl RE;Ladouceur CD
抑郁的年轻人在社会认知处理区域（STC和MPFC）对社会地位词的大脑激活减少。健康的年轻人在这些大脑区域中对社会地位（与中性词相比）的社会认知处理没有差异。抑郁的青年也表现出减少DLPFC和梭状回反应消极的，相比积极的，社会地位的话。年龄，而不是青春期的状态，与MPFC激活的社会地位的话。对社会地位的关注在青少年时期无处不在，有关社会地位的信息通常以文本形式传达。抑郁的青少年可能表现出支持处理社会地位信息的神经系统功能的改变。我们研究了抑郁的青年是否表现出改变神经激活的社会地位的话，在颞叶和前额叶皮质区被认为是参与社会认知处理，以及这种反应是否与发展。49名青少年（年龄10-18岁; 35名女性），包括20名重度抑郁症患者和29名对照组，在识别暗示积极和消极社会地位的单词的效价时进行了扫描。结果表明，抑郁的青年表现出减少后期激活的社会地位（相对于中性）的话，在上级颞叶皮层（STC）和内侧前额叶皮层（MPFC），而健康的青年没有表现出任何显着差异的文字类型。抑郁的青年也表现出减少晚激活背外侧前额叶皮层和梭状回消极（与积极）的社会地位的话，而健康的青年表现出相反的模式。最后，年龄与MPFC激活的社会地位的话。研究结果表明，“社会认知脑网络”的低激活可能与青少年抑郁症的人际功能改变有关。
Depressed youth show reduced brain activation to social status words in areas involved in social cognitive processing (STC and MPFC). Healthy youth don't differ in social cognitive processing of social status (compared to neutral) words in these brain regions. Depressed youth also show reduced DLPFC and fusiform gyrus response to negative, compared to positive, social status words. Age, but not pubertal status, was positively correlated with activation in MPFC to social status words. Concerns about social status are ubiquitous during adolescence, with information about social status often conveyed in text formats. Depressed adolescents may show alterations in the functioning of neural systems supporting processing of social status information. We examined whether depressed youth exhibited altered neural activation to social status words in temporal and prefrontal cortical regions thought to be involved in social cognitive processing, and whether this response was associated with development. Forty-nine adolescents (ages 10–18; 35 female), including 20 with major depressive disorder and 29 controls, were scanned while identifying the valence of words that connoted positive and negative social status. Results indicated that depressed youth showed reduced late activation to social status (vs neutral) words in the superior temporal cortex (STC) and medial prefrontal cortex (MPFC); whereas healthy youth did not show any significant differences between word types. Depressed youth also showed reduced late activation in the dorsolateral prefrontal cortex and fusiform gyrus to negative (vs positive) social status words; whereas healthy youth showed the opposite pattern. Finally, age was positively associated with MPFC activation to social status words. Findings suggest that hypoactivation in the “social cognitive brain network” might be implicated in altered interpersonal functioning in adolescent depression.
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影响因子：
4.2
作者：
Lieberman, Matthew D.;Inagaki, Tristen K.;Tabibnia, Golnaz;Crockett, Molly J.
通讯作者：
Crockett, Molly J.
影响因子：
3.7
作者：
Goddings AL;Burnett Heyes S;Bird G;Viner RM;Blakemore SJ
通讯作者：
Blakemore SJ
影响因子：
--
作者：
Herman-Giddens, ME
通讯作者：
Herman-Giddens, ME
DOI：
10.1016/j.jaac.2009.11.006
发表时间：
2010-02-01
影响因子：
13.3
作者：
Forbes, Erika E.;Ryan, Neal D.;Dahl, Ronald E.
通讯作者：
Dahl, Ronald E.
影响因子：
5.7
作者：
Handwerker, DA;Ollinger, JM;D'Esposito, M
通讯作者：
D'Esposito, M