Lipid deposition in rats centrally infused with leptin in the presence or absence of corticosterone.
Lipid deposition in rats centrally infused with leptin in the presence or absence of corticosterone.
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在存在或不存在皮质酮的情况下，集中注射瘦素的大鼠体内的脂质沉积。
DOI：
10.1152/ajpendo.2001.281.4.e809
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Y. Deshaies
中科院分区：
文献类型：
--
作者：
K. Arvaniti;D. Richard;F. Picard;Y. Deshaies
本研究的目的是评估糖皮质激素皮质酮 (Cort) 是否调节瘦素对食物摄入和脂质沉积的影响。大鼠接受为期 6 天的瘦素脑室内输注，并进行假肾上腺切除术 (Sham-ADX) 或 ADX，并补充 0 (C0)、40 (C40) 或 80 mg (C80) 的 Cort。对瘦素和 Cort 相互作用的潜在外周位点的研究包括肝脏和血浆甘油三酯 (TG) 含量以及脂肪和肌肉组织中的脂蛋白脂肪酶 (LPL) 活性。该研究证实了瘦素和 Cort 各自的厌食和食欲促进作用，并表明高剂量的 Cort 替代品抑制了瘦素引起的食物摄入量减少。然而，这种相互作用并没有延伸到身体和脂肪组织的重量，瘦素输注可降低身体和脂肪组织的重量，而与 Cort 状态无关。瘦素和 ADX 显着降低了肝脏 TG 含量和甘油三酯血症，而 Cort 替代显着增加了这些变量。瘦素的中央输注还降低了血浆胰岛素水平，同时降低了储存组织（腹股沟和附睾白色脂肪组织，分别为 2 倍和 3 倍）的 LPL 活性。相比之下，瘦素输注可增加氧化组织（比目鱼肌和股外侧肌，分别增加 3 倍和 4 倍）中的 LPL 活性。 Cort 替代疗法可防止 ADX 诱导的附睾 LPL 活性下降，但在注射瘦素的大鼠中却未能做到这一点。研究表明，虽然瘦素的食欲效应会因血浆皮质酮水平较高而受到抑制，但在生理性血浆水平上，瘦素可以在完整的下丘脑-垂体-肾上腺轴不存在或存在的情况下对体重、脂质运输和积累以及脂肪和肌肉 LPL 活性产生影响。
The aim of the present study was to assess whether the glucocorticoid corticosterone (Cort) modulates the effects of leptin on food intake and lipid deposition. Rats were subjected to a 6-day intracerebroventricular infusion of leptin and were either sham-adrenalectomized (Sham-ADX) or ADX and supplemented with 0 (C0), 40 (C40), or 80 mg (C80) of Cort. Investigation of potential peripheral sites of interaction of leptin and Cort included liver and plasma triglyceride (TG) content and lipoprotein lipase (LPL) activity in adipose and muscle tissues. The study confirmed the respective anorectic and orexigenic effects of leptin and Cort and revealed that the leptin-induced reduction in food intake was dampened by the high dose of Cort replacement. Such an interaction did not, however, extend to body and adipose tissue weights, which were lowered by leptin infusion independently of the Cort status. Leptin and ADX significantly reduced liver TG content and triglyceridemia, whereas Cort replacement significantly increased these variables. Central infusion of leptin also lowered plasma insulin levels, accompanied by a reduction in LPL activity of storage tissues (inguinal and epididymal white adipose tissue, 2- and 3-fold, respectively). In contrast, leptin infusion increased LPL activity in oxidative tissues (soleus and vastus lateralis muscles, 3- and 4-fold, respectively). Cort replacement prevented the ADX-induced fall in epididymal LPL activity but failed to do so in leptin-infused rats. The study demonstrates that, whereas the anorectic effect of leptin is dampened by high but physiological plasma levels of corticosterone, leptin can produce its effects on body weight, lipid transport and accumulation, and adipose and muscle LPL activity in the absence or presence of an intact hypothalamic-pituitary-adrenal axis.
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DOI：
10.1152/ajpendo.1998.275.2.e259
发表时间：
1998-08-01
影响因子：
5.1
作者：
Scarpace, PJ;Matheny, M
通讯作者：
Matheny, M
肥胖受试者对地塞米松的强劲瘦素分泌反应。
DOI：
10.1210/jcem.82.10.4154
发表时间：
1997
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Dagogo-Jack,S;Selke,G;Melson,AK;Newcomer,JW
通讯作者：
Newcomer,JW
DOI：
10.1073/pnas.94.16.8878
发表时间：
1997-08-05
影响因子：
11.1
作者：
Halaas, JL;Boozer, C;Friedman, JM
通讯作者：
Friedman, JM
DOI：
10.1093/jn/127.10.2065
发表时间：
1997-10
期刊：
The Journal of nutrition
影响因子：
--
作者：
A. Mistry;Swick Andrew Gordon;D. Romsos
通讯作者：
A. Mistry;Swick Andrew Gordon;D. Romsos
影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM