Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly.
Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly.
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DOI：
10.1371/journal.pone.0020158
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Schiöth HB
中科院分区：
文献类型：
--
作者：
Jacobsson JA;Almén MS;Benedict C;Hedberg LA;Michaëlsson K;Brooks S;Kullberg J;Axelsson T;Johansson L;Ahlström H;Fredriksson R;Lind L;Schiöth HB
脂肪量和肥胖（FTO）基因中的rs9939609单核苷酸多态性（SNP）以前与儿童和年轻人的BMI水平较高有关。相反，在老年男性中没有发现这种关联。BMI是衡量超重与个人身高的一个指标，但不能提供对局部身体脂肪组成或分布的了解。为了研究FTO基因是否与超重和身体组成相关的表型而不是BMI相关，我们测量了985名70岁的人（493名女性）的腰围，总脂肪量，躯干脂肪量，腿部脂肪量，内脏和皮下脂肪组织以及每日能量摄入量。总共对位于FTO基因中的733个SNP进行了基因分型，以检查rs9939609单独或其他SNP或其组合是否与老年人的肥胖相关措施有关。乌普萨拉老年人血管系统前瞻性研究（PIVUS）队列的横断面分析。无论是单一SNP，如rs9939609，还是SNP组合，都与老年人的超重，身体成分相关指标或每日能量摄入量无关。值得注意的是，这些观察结果在男性和女性中均成立。由于研究中包含的测量方法的多样性，我们的研究结果加强了这样一种观点，即与年轻人相比，FTO对身体成分的影响在晚年似乎不那么深刻，而且这似乎与性别无关。
The rs9939609 single-nucleotide polymorphism (SNP) in the fat mass and obesity (FTO) gene has previously been associated with higher BMI levels in children and young adults. In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the individuals' height, but offers no insight into the regional body fat composition or distribution. To examine whether the FTO gene is associated with overweight and body composition-related phenotypes rather than BMI, we measured waist circumference, total fat mass, trunk fat mass, leg fat mass, visceral and subcutaneous adipose tissue, and daily energy intake in 985 humans (493 women) at the age of 70 years. In total, 733 SNPs located in the FTO gene were genotyped in order to examine whether rs9939609 alone or the other SNPs, or their combinations, are linked to obesity-related measures in elderly humans. Cross-sectional analysis of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Neither a single SNP, such as rs9939609, nor a SNP combination was significantly linked to overweight, body composition-related measures, or daily energy intake in elderly humans. Of note, these observations hold both among men and women. Due to the diversity of measurements included in the study, our findings strengthen the view that the effect of FTO on body composition appears to be less profound in later life compared to younger ages and that this is seemingly independent of gender.
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影响因子：
7.7
作者：
Adeyemo A;Chen G;Zhou J;Shriner D;Doumatey A;Huang H;Rotimi C
通讯作者：
Rotimi C
影响因子：
--
作者：
Hennig BJ;Fulford AJ;Sirugo G;Rayco-Solon P;Hattersley AT;Frayling TM;Prentice AM
通讯作者：
Prentice AM
DOI：
10.1016/s0197-2456(98)00037-3
发表时间：
1998-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Dupont, WD;Plummer, WD
通讯作者：
Plummer, WD
影响因子：
11.4
作者：
Fawcett, Katherine A.;Barroso, Ines
通讯作者：
Barroso, Ines
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D