The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development.

The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development.
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DOI:
10.1016/j.neubiorev.2016.07.036
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发表时间:
2016-11
影响因子:
8.2
通讯作者:
Sisk, Cheryl L.
Sisk, Cheryl L.
中科院分区:
医学1区
文献类型:
--
作者:
Schulz, Kalynn M.;Sisk, Cheryl L.

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青春期是一个以认知、冒险和社会行为的急剧变化为特征的发展时期。虽然性腺类固醇激素是成年期这些行为的众所周知的介质,但性腺类固醇激素在塑造青少年大脑和行为发育中的作用只是近年来才被发现。在这里,我们讨论了性别特异性的影响,性腺类固醇激素对发育中的青少年大脑。事实上,青春期性腺类固醇激素对大脑结构和行为结果的影响在性别之间存在显着差异。研究结果表明,青春期和围产期一样,是性腺类固醇激素对大脑和行为发育的性别特异性影响的敏感期。此外,对男性性行为的研究证据表明,青春期是一个漫长的产后敏感期的一部分,从围产期开始,在青春期结束。因此,大脑和行为组织的围产期和青春期可能并不代表两个离散的敏感期,而是男性和女性性腺激素分泌的规范发育时间的结果。
Adolescence is a developmental period characterized by dramatic changes in cognition, risk-taking and social behavior. Although gonadal steroid hormones are well-known mediators of these behaviors in adulthood, the role gonadal steroid hormones play in shaping the adolescent brain and behavioral development has only come to light in recent years. Here we discuss the sex-specific impact of gonadal steroid hormones on the developing adolescent brain. Indeed, the effects of gonadal steroid hormones during adolescence on brain structure and behavioral outcomes differs markedly between the sexes. Research findings suggest that adolescence, like the perinatal period, is a sensitive period for the sex-specific effects of gonadal steroid hormones on brain and behavioral development. Furthermore, evidence from studies on male sexual behavior suggests that adolescence is part of a protracted postnatal sensitive period that begins perinatally and ends following adolescence. As such, the perinatal and peripubertal periods of brain and behavioral organization likely do not represent two discrete sensitive periods, but instead are the consequence of normative developmental timing of gonadal hormone secretions in males and females.
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