Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions.

Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions.
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DOI:
10.1038/nn.2178
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发表时间:
2008-09
影响因子:
25
通讯作者:
Sisk, Cheryl L.
Sisk, Cheryl L.
中科院分区:
医学1区
文献类型:
--
作者:
Ahmed, Eman I.;Zehr, Julia L.;Schulz, Kalynn M.;Lorenz, Betty H.;DonCarlos, Lydia L.;Sisk, Cheryl L.

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在青春期,包括神经元在内的新细胞在大鼠的几个大脑区域出现。青春期细胞增加的性别差异与成年期的两性二态性相一致:对于每个区域,在青春期获得更多细胞的性别在成年期具有更大的体积。在青春期前去除性腺激素可以消除这些性别差异,这表明性腺类固醇在青春期指导新细胞的增加,以维持和强调成人大脑中的性二态性。
New cells, including neurons, arise in several brain regions during puberty in rats. Sex differences in pubertal addition of cells coincide with adult sexual dimorphisms: for each region, the sex that gains more cells during puberty has a larger volume in adulthood. Removing gonadal hormones before puberty eliminates these sex differences, indicating that gonadal steroids direct the addition of new cells during puberty to maintain and accentuate sexual dimorphisms in the adult brain.
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