The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemic.
The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemic.
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DOI：
10.1111/pai.13361
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Byrareddy SN
中科院分区：
文献类型：
--
作者：
Rothan HA;Byrareddy SN
COVID-19 大流行期间的儿童多系统炎症综合征 (MIS-C) 向疾病控制与预防中心的健康警报网络发出了全球警报。 MIS-C（也称为儿科 MIS (PMIS)）在严重炎症状态下的主要表现包括发烧、腹泻、休克以及不同程度的皮疹、结膜炎、四肢水肿和粘膜变化。在某些情况下，这些症状会发展为多器官衰竭。与轻度疾病和中度疾病儿童相比，无症状病例的比例较低，这可能与 MIS-C 病例的罕见有关。尽管存在易于检测的抗 SARS-CoV-2 抗体，但仍进展为严重 MIS-C 疾病的一种可能解释可能是抗体依赖性增强 (ADE) 的潜在作用。我们推断，在针对 SARS-CoV-2 的疫苗开发中，应考虑病原体特异性抗体可促进病理的 ADE 现象的发生。
Multisystem inflammatory syndrome in children (MIS-C) during the COVID-19 pandemic raised a global alert from the Centers for Disease Control and Prevention’s Health Alert Network. The main manifestations of MIS-C (also known as pediatric MIS (PMIS)) in the setting of a severe inflammatory state include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes. In some cases, these symptoms progressed to multi-organ failure. The low percentage of children with asymptomatic cases compared with mild illness and moderate illness could be correlated with the rare cases of MIS-C. One potential explanation for the progression to severe MIS-C disease despite the presence of readily detectable anti-SARS-CoV-2 antibodies could be due to the potential role of antibody-dependent enhancement (ADE). We reason that the incidence of the ADE phenomenon whereby the pathogen-specific antibodies can promote pathology should be considered in vaccine development against SARS-CoV-2.
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影响因子：
5.4
作者：
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