Tissue engineering in the gut: developments in neuromusculature.
Tissue engineering in the gut: developments in neuromusculature.
复制标题
DOI：
10.1053/j.gastro.2014.03.044
复制
发表时间：
2014-06
期刊：
影响因子：
29.4
通讯作者：
Zakhem E
中科院分区：
文献类型：
--
作者：
Bitar KN;Raghavan S;Zakhem E
胃肠道（GI）的复杂性在于其解剖学和生理学。几种不同的细胞类型填充胃肠道，增加了再生医学细胞来源的复杂性。每个细胞层在调节消化、吸收、分泌、运动和排泄方面具有专门的功能。组织工程和再生医学的目标是再生模仿建筑和重演功能的特定层。胃肠动力是调节肠道作为一个器官的各种功能的基本程序。因此，第一个合乎逻辑的步骤，在胃肠道再生医学是重建管状光滑肌肉组织沿着与驱动器的输入，肠神经系统。胃肠道组织工程领域的最新进展集中在支架生物材料与细胞和生物活性因子的组合使用上。神经支配生物工程肌肉的能力是确保适当功能的关键步骤。最后，体内研究对于评价植入物与宿主组织的整合、存活和功能至关重要。在这篇综述中，我们将重点介绍胃肠道的管状结构，神经支配的工具，并最终评估在体内胃肠道替代策略。
The complexity of the gastrointestinal (GI) tract lies in its anatomy as well as in its physiology. Several different cell types populate the GI tract adding to the complexity of cell sourcing for regenerative medicine. Each cell layer has a specialized function in mediating digestion, absorption, secretion, motility and excretion. Tissue engineering and regenerative medicine aim to regenerate the specific layers mimicking architecture and recapitulating function. Gastrointestinal motility is the underlying program that mediates the diverse functions of the intestines, as an organ. Hence, the first logical step in GI regenerative medicine is the reconstruction of the tubular smooth musculature along with the drivers of their input, the enteric nervous system. Recent advances in the field of GI tissue engineering have focused on the use of scaffolding biomaterials in combination with cells and bioactive factors. The ability to innervate the bioengineered muscle is a critical step to ensure proper functionality. Finally, in vivo studies are essential to evaluate implant integration with host tissue, survival and functionality. In this review, we will focus on the tubular structure of the GI tract, tools for innervation and finally evaluation of in vivo strategies for GI replacements.
登录
查看更多内容
影响因子：
9
作者：
Grikscheit, TC;Siddique, A;Vacanti, JP
通讯作者：
Vacanti, JP
影响因子：
4.8
作者：
Davis, Brandi N.;Hilyard, Aaron C.;Hata, Akiko
通讯作者：
Hata, Akiko
DOI：
10.1152/ajpcell.2000.279.2.c529
发表时间：
2000-08-01
影响因子：
5.5
作者：
Epperson, A;Hatton, WJ;Horowitz, B
通讯作者：
Horowitz, B
影响因子：
24.5
作者：
Costa, M.;Brookes, S. J. H.;Hennig, G. W.
通讯作者：
Hennig, G. W.
影响因子：
9.8
作者：
De Giorgio, R;Di Simone, MP;Corinaldesi, R
通讯作者：
Corinaldesi, R