Integrating Environment and Aging Research: Opportunities for Synergy and Acceleration.
Integrating Environment and Aging Research: Opportunities for Synergy and Acceleration.
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整合环境和老化研究：协同和加速的机会。
DOI：
10.3389/fnagi.2022.824921
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发表时间：
2022
影响因子：
4.8
通讯作者：
Ottinger MA
中科院分区：
文献类型：
--
作者：
Malecki KMC;Andersen JK;Geller AM;Harry GJ;Jackson CL;James KA;Miller GW;Ottinger MA
尽管在任务上存在重大重叠，但环境健康科学和衰老生物学领域才刚刚开始交叉。越来越清楚的是，单靠遗传学并不能预测一个人的神经衰老和对疾病的敏感性。因此，老化神经科学是环境健康科学中一个日益受到共同关注的领域。这篇综述的动力来自于2020年6月由美国国家科学院、工程和医学研究院主办的一个研讨会，该研讨会的重点是整合衰老科学和环境健康研究。至关重要的是，要了解环境毒物暴露和与年龄相关的结果的影响，必须将学科与跨毒理学、比较生物学、流行病学的多学科合作联系起来。这一范围审查旨在突出现有知识中的重叠和差距，并确定基本的研究举措。它首先概述衰老生物学和生物标记物，然后是与环境健康科学协同作用的例子。还讨论了协同研究和政策制定的新领域。包括下一代测序和其他组学工具在内的技术进步现在提供了新的机会，包括暴露研究，将老化的生物标记物纳入环境健康评估并弥合学科差距。这对于更全面地理解一生暴露于毒物和其他身体和社会应激源是如何改变生物衰老是必要的。环境健康科学中新的累积风险框架承认，暴露和其他外部应激源可以在整个生命过程中积累，基于衰老生物学的暴露和反应的新生物标记物的进步可以支持对人口脆弱性的更多了解。识别广义的环境应激源对衰老生物学和神经科学的作用，同样可以促进干预和转化性研究的机会。几个日益引起研究兴趣的领域包括扩大暴露组学和使用多重组学，微生物组作为环境应激源、有毒混合物和神经生物学的媒介，以及结构性和历史边缘化和种族主义在形成人口老龄化和结果方面持续差异方面的作用。需要在环境健康科学中进行综合的基础性和转化性衰老生物学研究，以改善政策，减少差距，并提高老年人的生活质量。
Despite significant overlaps in mission, the fields of environmental health sciences and aging biology are just beginning to intersect. It is increasingly clear that genetics alone does not predict an individual’s neurological aging and sensitivity to disease. Accordingly, aging neuroscience is a growing area of mutual interest within environmental health sciences. The impetus for this review came from a workshop hosted by the National Academies of Sciences, Engineering, and Medicine in June of 2020, which focused on integrating the science of aging and environmental health research. It is critical to bridge disciplines with multidisciplinary collaborations across toxicology, comparative biology, epidemiology to understand the impacts of environmental toxicant exposures and age-related outcomes. This scoping review aims to highlight overlaps and gaps in existing knowledge and identify essential research initiatives. It begins with an overview of aging biology and biomarkers, followed by examples of synergy with environmental health sciences. New areas for synergistic research and policy development are also discussed. Technological advances including next-generation sequencing and other-omics tools now offer new opportunities, including exposomic research, to integrate aging biomarkers into environmental health assessments and bridge disciplinary gaps. This is necessary to advance a more complete mechanistic understanding of how life-time exposures to toxicants and other physical and social stressors alter biological aging. New cumulative risk frameworks in environmental health sciences acknowledge that exposures and other external stressors can accumulate across the life course and the advancement of new biomarkers of exposure and response grounded in aging biology can support increased understanding of population vulnerability. Identifying the role of environmental stressors, broadly defined, on aging biology and neuroscience can similarly advance opportunities for intervention and translational research. Several areas of growing research interest include expanding exposomics and use of multi-omics, the microbiome as a mediator of environmental stressors, toxicant mixtures and neurobiology, and the role of structural and historical marginalization and racism in shaping persistent disparities in population aging and outcomes. Integrated foundational and translational aging biology research in environmental health sciences is needed to improve policy, reduce disparities, and enhance the quality of life for older individuals.
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影响因子：
3.7
作者：
Brieño-Enríquez MA;García-López J;Cárdenas DB;Guibert S;Cleroux E;Děd L;Hourcade Jde D;Pěknicová J;Weber M;Del Mazo J
通讯作者：
Del Mazo J
DOI：
10.1093/gerona/57.5.m283
发表时间：
2002-05-01
影响因子：
5.1
作者：
Bortz, WM
通讯作者：
Bortz, WM
影响因子：
4.6
作者：
Cardenas A;Rifas-Shiman SL;Agha G;Hivert MF;Litonjua AA;DeMeo DL;Lin X;Amarasiriwardena CJ;Oken E;Gillman MW;Baccarelli AA
通讯作者：
Baccarelli AA
影响因子：
7.8
作者：
Castro-Mejia, Josue L.;Khakimov, Bekzod;Nielsen, Dennis S.
通讯作者：
Nielsen, Dennis S.
DOI：
10.3390/ijerph17197056
发表时间：
2020-09-27
影响因子：
--
作者：
Black K;Jester DJ
通讯作者：
Jester DJ