The age and evolution of an antiviral resistance mutation in Drosophila melanogaster.
The age and evolution of an antiviral resistance mutation in Drosophila melanogaster.
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果蝇抗病毒抗性突变的年龄和演变。
DOI：
10.1098/rspb.2007.0611
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发表时间：
2007-08-22
影响因子：
4.7
通讯作者：
Jiggins, Francis M.
中科院分区：
文献类型：
--
作者：
Bangham, Jenny;Obbard, Darren J.;Kim, Kang-Wook;Haddrill, Penelope R.;Jiggins, Francis M.
寄生虫及其宿主进化的基础是什么选择过程？军备竞赛模型提出，新的宿主抗性突变或寄生虫反适应会出现并席卷固定。频率依赖模型提出，选择有利于适应最常见宿主基因型的病原体，从而赋予稀有宿主基因型优势。从经验上来说，区分这些模型是很困难的。人们对植物中抗病多态性的维持进行了详细研究，但在动物中研究较少，在自然群体中也很少研究。我们对自然动物群体黑腹果蝇及其天然病原体西格玛病毒的宿主抗性遗传变异进行了详细研究。我们证实了之前的发现，即基因 ref(2)P 中的单个（尽管复杂）突变赋予了对 sigma 的抗性，并表明该突变在正选择下频率增加。先前的研究表明，ref(2)P 多态性反映了最近选择性清除的进展，并且在 20 世纪 80 年代的欧洲，随后进行了能够感染携带这种突变的果蝇的 Sigma 病毒株的清除。我们发现 ref(2)P 抗性突变比该病毒株最近传播的时间要早得多，并且表明（可能是因为它是隐性的）抗性突变的初始传播非常缓慢。
What selective processes underlie the evolution of parasites and their hosts? Arms-race models propose that new host-resistance mutations or parasite counter-adaptations arise and sweep to fixation. Frequency-dependent models propose that selection favours pathogens adapted to the most common host genotypes, conferring an advantage to rare host genotypes. Distinguishing between these models is empirically difficult. The maintenance of disease-resistance polymorphisms has been studied in detail in plants, but less so in animals, and rarely in natural populations. We have made a detailed study of genetic variation in host resistance in a natural animal population, Drosophila melanogaster, and its natural pathogen, the sigma virus. We confirm previous findings that a single (albeit complex) mutation in the gene ref(2)P confers resistance against sigma and show that this mutation has increased in frequency under positive selection. Previous studies suggested that ref(2)P polymorphism reflects the progress of a very recent selective sweep, and that in Europe during the 1980s, this was followed by a sweep of a sigma virus strain able to infect flies carrying this mutation. We find that the ref(2)P resistance mutation is considerably older than the recent spread of this viral strain and suggest that—possibly because it is recessive—the initial spread of the resistance mutation was very slow.
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影响因子：
11.4
作者：
DEZELEE, S;BRAS, F;TENINGES, D
通讯作者：
TENINGES, D
影响因子：
1.5
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FLEURIET, A;PERIQUET, G;ANXOLABEHERE, D
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ANXOLABEHERE, D
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Schauser L