CoaSim: a flexible environment for simulating genetic data under coalescent models.
CoaSim: a flexible environment for simulating genetic data under coalescent models.
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DOI：
10.1186/1471-2105-6-252
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发表时间：
2005-10-14
影响因子：
3
通讯作者：
Schauser L
中科院分区：
文献类型：
--
作者：
Mailund T;Schierup MH;Pedersen CN;Mechlenborg PJ;Madsen JN;Schauser L
聚结模拟在解释大规模种内序列或多态性调查以及规划和评估关联研究中发挥着重要作用。不同模型下的数据集的聚结模拟可以与实际数据进行比较，以测试不同进化因素的重要性，从而深入了解这些因素。我们已经创建了CoaSim应用程序，作为一个灵活的环境，用于在平衡和非平衡聚结过程中对各种类型的遗传数据进行蒙特卡罗模拟，用于各种应用。与该工具的交互是通过Scheme脚本语言的Guile版本进行的。提供了许多标准和高级应用程序的方案脚本，用户可以轻松地修改这些脚本，以适应更广泛的应用程序。还包括功能性和灵活性较少的图形用户界面。CoaSim是一个功能强大的工具，因为它的灵活性和易用性。这是通过应用程序的各种用途来说明的，例如，关联映射方法的评估、参数自举以及针对特定问题的标记的设计和选择
Coalescent simulations are playing a large role in interpreting large scale intra-specific sequence or polymorphism surveys and for planning and evaluating association studies. Coalescent simulations of data sets under different models can be compared to the actual data to test the importance of different evolutionary factors and thus get insight into these. We have created the CoaSim application as a flexible environment for Monte Carlo simulation of various types of genetic data under equilibrium and non-equilibrium coalescent processes for a variety of applications. Interaction with the tool is through the Guile version of the Scheme scripting language. Scheme scripts for many standard and advanced applications are provided and these can easily be modified by the user for a much wider range of applications. A graphical user interface with less functionality and flexibility is also included. It is primarily intended as an exploratory and educational tool CoaSim is a powerful tool because of its flexibility and ease of use. This is illustrated through very varied uses of the application, e.g. evaluation of association mapping methods, parametric bootstrapping, and design and choice of markers for specific questions
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影响因子：
5.8
作者：
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通讯作者：
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