Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation.
Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation.
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复杂的促成复合体/循环体的复杂调节机制及其在染色质调节中的作用。
DOI：
10.3389/fcell.2021.687515
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发表时间：
2021
影响因子：
5.5
通讯作者：
Brown NG
中科院分区：
文献类型：
--
作者：
Bodrug T;Welsh KA;Hinkle M;Emanuele MJ;Brown NG
泛蛋白（Ub）-蛋白酶体系统对真核生物中几乎所有生物过程都至关重要。具体而言，通过Ub连接酶（如后期促进复合物/环体（APC/C））将Ub缀合至靶蛋白对于细胞周期转换是至关重要的，因为它导致蛋白酶体对细胞周期调节剂的不可逆破坏。通过这种活性，RING Ub连接酶APC/C控制有丝分裂、G1期和神经生物学的许多方面。开创性的cryo-EM，生化重建和基于细胞的研究已经阐明了这种大型多亚基复合物的构象动力学和APC/C功能的复杂调节的许多方面。最近的研究揭示了选择性地决定APC/C活性的新机制，并探索了由APC/C介导的泛素化控制的其他途径，包括与染色质调控的密切关系。这些任务超越了历史上归因于APC/C的传统细胞周期作用。在这里，我们回顾了这些新的发现，研究APC/C调节的机制影响，并讨论了APC/C在以前未被重视的信号通路中的作用。
The ubiquitin (Ub)-proteasome system is vital to nearly every biological process in eukaryotes. Specifically, the conjugation of Ub to target proteins by Ub ligases, such as the Anaphase-Promoting Complex/Cyclosome (APC/C), is paramount for cell cycle transitions as it leads to the irreversible destruction of cell cycle regulators by the proteasome. Through this activity, the RING Ub ligase APC/C governs mitosis, G1, and numerous aspects of neurobiology. Pioneering cryo-EM, biochemical reconstitution, and cell-based studies have illuminated many aspects of the conformational dynamics of this large, multi-subunit complex and the sophisticated regulation of APC/C function. More recent studies have revealed new mechanisms that selectively dictate APC/C activity and explore additional pathways that are controlled by APC/C-mediated ubiquitination, including an intimate relationship with chromatin regulation. These tasks go beyond the traditional cell cycle role historically ascribed to the APC/C. Here, we review these novel findings, examine the mechanistic implications of APC/C regulation, and discuss the role of the APC/C in previously unappreciated signaling pathways.
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影响因子：
64.5
作者：
Bassermann, Florian;Frescas, David;Guardavaccaro, Daniele;Busino, Luca;Peschiaroli, Angelo;Pagano, Michele
通讯作者：
Pagano, Michele
影响因子：
16
作者：
Brown, Nicholas G.;Watson, Edmond R.;Weissmann, Florian;Jarvis, Marc A.;VanderLinden, Ryan;Grace, Christy R. R.;Frye, Jeremiah J.;Qiao, Renping;Dube, Prakash;Petzold, Georg;Cho, Shein Ei;Alsharif, Omar;Bao, Ju;Davidson, Iain F.;Zheng, Jie J.;Nourse, Amanda;Kurinov, Igor;Peters, Jan-Michael;Stark, Holger;Schulman, Brenda A.
通讯作者：
Schulman, Brenda A.
影响因子：
64.8
作者：
Alfieri, Claudio;Chang, Leifu;Zhang, Ziguo;Yang, Jing;Maslen, Sarah;Skehel, Mark;Barford, David
通讯作者：
Barford, David
影响因子：
9.3
作者：
Barr AR;Heldt FS;Zhang T;Bakal C;Novák B
通讯作者：
Novák B
影响因子：
9.8
作者：
Ajeawung, Norbert F.;Thi Tuyet Mai Nguyen;Campeau, Philippe M.
通讯作者：
Campeau, Philippe M.