Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative.
Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative.
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DOI：
10.1186/s13075-021-02422-0
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发表时间：
2021-01-19
影响因子：
4.9
通讯作者：
Walsh DA
中科院分区：
文献类型：
--
作者：
Aso K;Shahtaheri SM;McWilliams DF;Walsh DA
膝关节骨性关节炎（OA）在MRI上发现的软骨下骨髓病变（BMLs）与膝关节疼痛有关。膝关节机械负荷增加了软骨下脑损伤的发病率和进展。然而，软骨下BML位置与负重膝关节疼痛的关系目前尚不清楚。在这项研究中，我们的目的是证明软骨下BML的位置和大小与膝关节OA的负重膝关节疼痛的关系。我们分别分析了来自横截面和纵向骨关节炎倡议数据集的1412例和582例膝内翻。用MRI骨关节炎膝关节评分对4个软骨下区域（股胫正中和外侧、髌骨内侧和外侧）和棘下区域的BML评分进行半定量分析。负重和非负重疼痛评分来源于WOMAC疼痛项目。采用相关回归模型和负二项回归模型分析基线时BML评分与疼痛的关系以及随访24个月后BML评分与疼痛变化的关系。股骨胫骨内侧和髌股外侧腔室BML评分越高，负重疼痛评分越高，在校正其他4个关节腔室BML评分和其他OA特征，以及非负重疼痛、年龄、性别和体重指数（BMI）（股胫内侧；B = 0.08, p = 0.02）后，仍具有统计学意义。髌股的;B = 0.13, p = 0.01)。亚分析显示，内侧股胫BML评分越高，行走和站立时疼痛越严重（B = 0.11, p = 0.01, B = 0.10, p = 0.04）。髌骨外侧BML评分分别与攀爬疼痛相关（B = 0.14, p = 0.02）。在调整非负重疼痛、年龄、性别、基线负重疼痛、BMI和其他4个关节室BML后，股骨胫骨内侧室BML评分在24个月内的升高或降低与负重疼痛严重程度的升高或降低显著相关（B = 0.10, p = 0.01）。股骨胫骨内侧关节室软骨下BML的大小与膝关节OA中负重疼痛的严重程度和变化特别相关，独立于非负重疼痛。负重疼痛与膝关节负重腔室软骨下骨髓炎的特殊关联表明，软骨下骨的骨髓炎有助于生物力学诱导的OA疼痛。在线版本包含补充材料，可在10.1186/s13075-021-02422-0获得。
Subchondral bone marrow lesions (BMLs) detected on MRI in knee osteoarthritis (OA) are associated with knee pain. The prevalence and progression of subchondral BMLs are increased by mechanical knee load. However, associations of subchondral BML location with weight-bearing knee pain are currently unknown. In this study, we aim to demonstrate associations of subchondral BML location and size with weight-bearing knee pain in knee OA. We analyzed 1412 and 582 varus knees from cross-sectional and longitudinal Osteoarthritis Initiative datasets, respectively. BML scores were semi-quantitatively analyzed with the MRI Osteoarthritis Knee Score for 4 subchondral regions (median and lateral femorotibial, medial and lateral patellofemoral) and subspinous region. Weight-bearing and non-weight-bearing pain scores were derived from WOMAC pain items. Correlation and negative binomial regression models were used for analysis of associations between the BML scores and pain at baseline and changes in the BML scores and changes in pain after 24-month follow-up. Greater BML scores at medial femorotibial and lateral patellofemoral compartments were associated with greater weight-bearing pain scores, and statistical significance was retained after adjusting for BML scores at the other 4 joint compartments and other OA features, as well as for non-weight-bearing pain, age, sex, and body mass index (BMI) (medial femorotibial; B = 0.08, p = 0.02. patellofemoral; B = 0.13, p = 0.01). Subanalysis revealed that greater medial femorotibial BML scores were associated with greater pain on walking and standing (B = 0.11, p = 0.01, and B = 0.10, p = 0.04, respectively). Lateral patellofemoral BML scores were associated with pain on climbing, respectively (B = 0.14, p = 0.02). Increases or decreases over 24 months in BML score in the medial femorotibial compartment were significantly associated with increases or decreases in weight-bearing pain severity after adjusting for non-weight-bearing pain, age, sex, baseline weight-bearing pain, BMI, and BML at the other 4 joint compartments (B = 0.10, p = 0.01). Subchondral BML size at the medial femorotibial joint compartment was specifically associated with the severity and the change in weight-bearing pain, independent of non-weight-bearing pain, in knee OA. Specific associations of weight-bearing pain with subchondral BMLs in weight-bearing compartments of the knee indicate that BMLs in subchondral bone contribute to biomechanically induced OA pain. The online version contains supplementary material available at 10.1186/s13075-021-02422-0.
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影响因子：
--
作者：
Moisio, Kirsten;Eckstein, Felix;Chmiel, Joan S.;Guermazi, Ali;Prasad, Pottumarthi;Almagor, Orit;Song, Jing;Dunlop, Dorothy;Hudelmaier, Martin;Kothari, Ami;Sharma, Leena
通讯作者：
Sharma, Leena
DOI：
10.1002/art.23326
发表时间：
2008-03-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Hinman, Rana S.;Payne, Craig;Bennell, Kim L.
通讯作者：
Bennell, Kim L.
DOI：
10.1002/art.22990
发表时间：
2007-10-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Racunica, Tina L.;Teichtahl, Andrew J.;Cicuttini, Flavia M.
通讯作者：
Cicuttini, Flavia M.
影响因子：
--
作者：
Hunter, David J.;Zhang, Yuqing;Felson, David T.
通讯作者：
Felson, David T.
影响因子：
2.1
作者：
Stahl, Robert;Jain, Sapna K.;Lutz, Juergen;Wyman, Bradley T.;Le Graverand-Gastineau, Marie-Pierre Hellio;Vignon, Eric;Majumdar, Sharmila;Link, Thomas M.
通讯作者：
Link, Thomas M.