Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study.
Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study.
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DOI：
10.1007/s00256-011-1156-9
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发表时间：
2011-10
影响因子：
2.1
通讯作者：
Link, Thomas M.
中科院分区：
文献类型：
--
作者：
Stahl, Robert;Jain, Sapna K.;Lutz, Juergen;Wyman, Bradley T.;Le Graverand-Gastineau, Marie-Pierre Hellio;Vignon, Eric;Majumdar, Sharmila;Link, Thomas M.
关键词：
比较半定量和定量形态学评分评估早期骨关节炎（OA）演变。3.0在60名女性中进行了膝关节的T MRI，其中30名为早期OA（各15名为Kelling-Lawrence 2级和3级），30名年龄匹配的对照组在基线和12个月和24个月时进行了膝关节T MRI检查。采用全器官磁共振成像评分（蠕虫）评估病理状况。软骨异常和骨髓水肿模式（BMEP）也使用先前引入的形态定量评分进行定量。使用广义估计方程（GEE）将这些数据与临床参数和关节间隙宽度的变化相关。在基线时，OA患者具有显著（p<0.05）更多和更大的软骨病变和BMEP。在随访期间，与对照组相比，患者的软骨病变显著增加（p<0.05）：蠕虫仅在髌骨外侧显示进展，而定量评分显示在髌骨和内侧间室也有进展。两个评分均显示OA患者股骨外侧的BMEP显著增加（p<0.05）。此外，患者12个月后全膝BMEP定量评分显著降低（p<0.05），24个月后增加，但在所有随访检查中，对照组均显示增加。仅观察到结构成像结果与临床参数之间的弱相关性。软骨病变和BMEP的定量评估比半定量评分对疾病过程中的变化更敏感。然而，结构成像结果与OA的临床进展并不相关。
To compare a semi-quantitative and a quantitative morphological score for assessment of early osteoarthritis (OA) evolution. 3.0 T MRI of the knee was performed in 60 women, 30 with early OA (each 15 with Kellgren–Lawrence grade 2 and 3) and 30 age-matched controls at baseline and at 12 and 24 months. Pathological condition was assessed with the whole-organ magnetic resonance imaging score (WORMS). Cartilage abnormalities and bone marrow edema pattern (BMEP) were also quantified using a previously introduced morphological quantitative score. These data were correlated with changes in clinical parameters and joint space width using generalized estimation equations (GEE). At baseline, OA patients had significantly (p<0.05) more and larger cartilage lesions and BMEP. During follow-up, cartilage lesions increased significantly (p<0.05) in the patients compared with controls: WORMS showed progression only at the lateral patella, whereas the quantitative score revealed progression additionally at the trochlea and at the medial compartment. Both scores showed a significant (p<0.05) increase in BMEP at the lateral femur in OA patients. In addition, quantitative scores of BMEP of the whole knee decreased significantly (p<0.05) after 12 months and increased after 24 months in the patients, but showed an increase in controls at all follow-up examinations. Only weak correlations between structural imaging findings and clinical parameters were observed. Quantitative assessment of cartilage lesions and BMEP is more sensitive to changes during the course of the disease than semi-quantitative scoring. However, structural imaging findings do not correlate well with the clinical progression of OA.
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影响因子：
7
作者：
Conrozier, T;Favret, H;Vignon, E
通讯作者：
Vignon, E
影响因子：
1.3
作者：
Fischbach, F;Bruhn, H;Schröder, RJ
通讯作者：
Schröder, RJ
影响因子：
19.7
作者：
Kijowski, Richard;Blankenbaker, Donna G.;De Smet, Arthur A.
通讯作者：
De Smet, Arthur A.
影响因子：
1.3
作者：
Brem, M. H.;Schlechtweg, P. M.;Lang, P.
通讯作者：
Lang, P.
影响因子：
27.4
作者：
Eckstein, F.;Buck, R. J.;Le Graverand, M-P Hellio
通讯作者：
Le Graverand, M-P Hellio