Neutrophil infiltration and systemic vascular inflammation in obese women.
Neutrophil infiltration and systemic vascular inflammation in obese women.
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DOI：
10.1177/1933719109348252
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Walsh SW
中科院分区：
文献类型：
--
作者：
Shah TJ;Leik CE;Walsh SW
肥胖症已经在全世界流行，在育龄妇女中尤为明显，这一点很重要，因为肥胖症是先兆子痫和慢性高血压的主要危险因素。我们假设血管炎症对肥胖者高血压的病理生理学至关重要，因为肥胖和高血压疾病具有与炎症相关的共同特征。为了研究这一点，我们收集了正常体重、超重和肥胖女性的皮下脂肪活检组织，并对中性粒细胞标志物CD66b以及作为炎症标志的激活核因子-κB(NF-κB)和环氧合酶-2(COX-2)进行了染色。结果发现，肥胖妇女的中性粒细胞数、CD66b、NF-κB和COX-2的血管染色百分率和染色强度在肥胖妇女中最高，而在正常体重妇女中最低，中性粒细胞浸润和血管炎症与体重指数和血压显著相关。这些数据可能有助于解释肥胖和高血压疾病之间的关系。
Obesity has become epidemic worldwide and is especially pronounced in women of reproductive age which is important because obesity is a major risk factor for preeclampsia and chronic hypertension. We hypothesized that vascular inflammation is critical to the pathophysiology of hypertension in obese individuals because obesity and hypertensive disorders share common features related to inflammation. To study this, we collected subcutaneous fat biopsies from normal weight, overweight and obese women and stained the tissues for CD66b, a neutrophil marker, and for activated nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) as markers of inflammation. We found that the number of neutrophils per vessel and the percentage and intensity of vessel staining for CD66b, NF-κB and COX-2 were greatest in obese women and least in normal weight women, and that neutrophil infiltration and vascular inflammation significantly correlated with BMI and blood pressure. These data may help explain the relationship between obesity and hypertensive disorders.
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作者：
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DOI：
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发表时间：
1998-01-01
期刊：
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY
影响因子：
--
作者：
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