Polypharmacy: misleading, but manageable.
Polypharmacy: misleading, but manageable.
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多药：具有误导性，但可以管理。
DOI：
10.2147/cia.s2468
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发表时间：
2008
影响因子：
3.6
通讯作者：
Simpson KN
中科院分区：
文献类型：
--
作者：
Bushardt RL;Massey EB;Simpson TW;Ariail JC;Simpson KN
老年人所占人口的比例正在增加，必须同时管理多种慢性疾病的更高流行率。医疗从业者必须适当地使用药物治疗多种疾病，并避免风险往往与多种药物的使用，如不良反应，药物/药物相互作用，药物/疾病相互作用，和不适当的剂量。本研究的目的是确定一个共识的定义为多药治疗，并评估其在老年门诊患者的患病率。作者还试图确定或开发一种临床工具，以帮助医疗保健从业人员防范老年患者的不适当药物治疗。最常引用的定义是药物与诊断不匹配。不适当是经常使用的定义的一部分。一些定义对合并用药给出了数值。两种常见的定义（即，6种或更多种药物或一种可能不适当的药物）被用来评估老年南卡罗来纳州（n = 1027）的多药治疗。数据分析表明，该人群中有相当大比例的人处方了6种或6种以上合并药物和/或使用了可能不适当的药物。结果是29.4%的患者同时使用6种或6种以上药物，15.7%的患者使用一种或多种可能不适当的药物，9.3%的患者符合本研究中使用的多种药物的定义。作者建议使用不太含糊的术语，如过度药物治疗或多种药物使用。一个结构化的方法来识别和管理不适当的多药的建议和临床工具。
The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effects, drug/drug interactions, drug/disease interactions, and inappropriate dosing. The purpose of this study is to identify a consensus definition for polypharmacy and evaluate its prevalence among elderly outpatients. The authors also sought to identify or develop a clinical tool which would assist healthcare practitioners guard against inappropriate drug therapy in elderly patients. The most commonly cited definition was a medication not matching a diagnosis. Inappropriate was part of definitions used frequently. Some definitions placed a numeric value on concurrent medications. Two common definitions (ie, 6 or more medications or a potentially inappropriate medication) were used to evaluate polypharmacy in elderly South Carolinians (n = 1027). Data analysis demonstrates that a significant percentage of this population is prescribed six or more concomitant drugs and/or uses a potentially inappropriate medication. The findings are 29.4% are prescribed 6 or more concurrent drugs, 15.7% are prescribed one or more potentially inappropriate drugs, and 9.3% meet both definitions of polypharmacy used in this study. The authors recommend use of less ambiguous terminology such as hyperpharmacotherapy or multiple medication use. A structured approach to identify and manage inappropriate polypharmacy is suggested and a clinical tool is provided.
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影响因子：
2.8
作者：
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通讯作者：
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通讯作者：
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