The Emerging Mechanisms of Wnt Secretion and Signaling in Development.
The Emerging Mechanisms of Wnt Secretion and Signaling in Development.
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DOI：
10.3389/fcell.2021.714746
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发表时间：
2021
影响因子：
5.5
通讯作者：
Chaudhary V
中科院分区：
文献类型：
--
作者：
Mehta S;Hingole S;Chaudhary V
Wnt是一种高度保守的脂质修饰分泌蛋白，可激活多种信号通路。这些通路在发育的各个阶段调节关键过程，并维持成年人的组织稳态。Wnt蛋白最吸引人的方面之一是，尽管是疏水性的，但已知它们在细胞外空间中旅行几个细胞距离。在过去的四十年中，对Wnt的研究已经确定了几个因素，并揭示了调节其表达，分泌和细胞外旅行模式的机制。最近，对Wnt蛋白梯度在发育组织的生长和图案化中的重要性的分析已经认识到有助于维持组织稳态的信号传导机制的复杂相互作用。本文综述了Wnt蛋白分泌和信号传导的各种模式的证据，并讨论了为发育组织提供精确性和鲁棒性的机制。
Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling pathways. These pathways regulate crucial processes during various stages of development and maintain tissue homeostasis in adults. One of the most fascinating aspects of Wnt protein is that despite being hydrophobic, they are known to travel several cell distances in the extracellular space. Research on Wnts in the past four decades has identified several factors and uncovered mechanisms regulating their expression, secretion, and mode of extracellular travel. More recently, analyses on the importance of Wnt protein gradients in the growth and patterning of developing tissues have recognized the complex interplay of signaling mechanisms that help in maintaining tissue homeostasis. This review aims to present an overview of the evidence for the various modes of Wnt protein secretion and signaling and discuss mechanisms providing precision and robustness to the developing tissues.
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影响因子：
2.7
作者：
Fisher, Malcolm E.;Clelland, Allyson K.;Bain, Andrew;Baldock, Richard A.;Murphy, Paula;Downie, Helen;Tickle, Cheryll;Davidson, Duncan R.;Buckland, Richard A.
通讯作者：
Buckland, Richard A.
DOI：
10.1111/tra.12016
发表时间：
2013-01
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Beckett K;Monier S;Palmer L;Alexandre C;Green H;Bonneil E;Raposo G;Thibault P;Le Borgne R;Vincent JP
通讯作者：
Vincent JP
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
64.8
作者：
Bhanot, P;Brink, M;Nusse, R
通讯作者：
Nusse, R
影响因子：
56.9
作者：
Bilic, Josipa;Huang, Ya-Lin;Niehrs, Christof
通讯作者：
Niehrs, Christof