Human Astrovirus 1-8 Seroprevalence Evaluation in a United States Adult Population.

Human Astrovirus 1-8 Seroprevalence Evaluation in a United States Adult Population.
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DOI:
10.3390/v13060979
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发表时间:
2021-05-25
期刊:
Viruses
影响因子:
--
通讯作者:
DuBois RM
DuBois RM
中科院分区:
其他
文献类型:
--
作者:
Meyer L;Delgado-Cunningham K;Lorig-Roach N;Ford J;DuBois RM

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人类星状病毒是全球病毒性胃肠炎的一个重要原因,但很少有研究调查成人的血清状态,以确定以前的感染率。在这里,我们应用生物层干涉免疫吸附测定(BLI-ISA),最近开发的血清监测技术,测量存在的血浆IgG抗体针对人类星状病毒衣壳刺突血清型1-8在美国成年人口的横断面样本。人星状病毒1型、3型、4型、5型、8型、2型、6型、7型IgG抗体阳性率分别为73%、62%、52%、29%、27%、22%、8%、8%。值得注意的是,衣壳刺突抗原的血清阳性率与先前确定的中和抗体率相关。这项工作是第一个血清阳性率研究评估所有八个经典的人类星状病毒血清型。
Human astroviruses are an important cause of viral gastroenteritis globally, yet few studies have investigated the serostatus of adults to establish rates of previous infection. Here, we applied biolayer interferometry immunosorbent assay (BLI-ISA), a recently developed serosurveillance technique, to measure the presence of blood plasma IgG antibodies directed towards the human astrovirus capsid spikes from serotypes 1–8 in a cross-sectional sample of a United States adult population. The seroprevalence rates of IgG antibodies were 73% for human astrovirus serotype 1, 62% for serotype 3, 52% for serotype 4, 29% for serotype 5, 27% for serotype 8, 22% for serotype 2, 8% for serotype 6, and 8% for serotype 7. Notably, seroprevalence rates for capsid spike antigens correlate with neutralizing antibody rates determined previously. This work is the first seroprevalence study evaluating all eight classical human astrovirus serotypes.
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