Human Astrovirus 1-8 Seroprevalence Evaluation in a United States Adult Population.
Human Astrovirus 1-8 Seroprevalence Evaluation in a United States Adult Population.
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DOI:
10.3390/v13060979
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发表时间:
2021-05-25
期刊:
影响因子:
--
通讯作者:
DuBois RM
中科院分区:
文献类型:
--
作者:
Meyer L;Delgado-Cunningham K;Lorig-Roach N;Ford J;DuBois RM
Human astroviruses are an important cause of viral gastroenteritis globally, yet few studies have investigated the serostatus of adults to establish rates of previous infection. Here, we applied biolayer interferometry immunosorbent assay (BLI-ISA), a recently developed serosurveillance technique, to measure the presence of blood plasma IgG antibodies directed towards the human astrovirus capsid spikes from serotypes 1–8 in a cross-sectional sample of a United States adult population. The seroprevalence rates of IgG antibodies were 73% for human astrovirus serotype 1, 62% for serotype 3, 52% for serotype 4, 29% for serotype 5, 27% for serotype 8, 22% for serotype 2, 8% for serotype 6, and 8% for serotype 7. Notably, seroprevalence rates for capsid spike antigens correlate with neutralizing antibody rates determined previously. This work is the first seroprevalence study evaluating all eight classical human astrovirus serotypes.
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DOI:
10.1073/pnas.1104834108
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