Associations between corpus callosum damage, clinical disability, and surface-based homologous inter-hemispheric connectivity in multiple sclerosis.
Associations between corpus callosum damage, clinical disability, and surface-based homologous inter-hemispheric connectivity in multiple sclerosis.
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DOI：
10.1007/s00429-022-02498-7
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发表时间：
2022-12
影响因子：
3.1
通讯作者：
Klawiter, Eric C.
中科院分区：
文献类型：
--
作者：
Russo, Andrew W.;Stockel, Kirsten E.;Tobyne, Sean M.;Ngamsombat, Chanon;Brewer, Kristina;Nummenmaa, Aapo;Huang, Susie Y.;Klawiter, Eric C.
关键词：
胼胝体轴突损伤在多发性硬化症（MS）中很常见。尽管胼胝体损伤与大脑半球之间的功能连接中断有关，但尚不清楚这与认知和身体残疾之间的关系。我们利用胼胝体微结构完整性和皮层表面同源半球间连通性（sHIC）的先进测量方法研究了这一现象。我们发现，与42名健康对照组相比，36名MS患者（29名复发缓解型MS， 4名继发进行性MS， 3名原发性进行性MS）的初级运动、体感觉、视觉和颞皮质区sHIC显著降低（聚类水平，p < 0.05）。在多发性硬化症患者中，整体sHIC与胼胝体后段分数各向异性和受限体积分数相关（r = 0.426, p = 0.013; r = 0.399, p = 0.020）。较低的sHIC，特别是在躯体运动区和后皮质区，与认知障碍和扩展残疾状态量表（EDSS）上较高的残疾评分相关。我们证明，高水平的sHIC减弱了后胼胝体损伤对身体残疾和认知功能障碍的影响，正如EDSS和简短视觉空间记忆测试修订（交互效应，p < 0.05）所测量的那样。我们还观察到全球sHIC与受教育年数之间存在正相关（r = 0.402, p = 0.018），支持MS中的“脑储备”现象。我们的数据表明，保留的sHIC有助于预防MS的认知和身体衰退。
Axonal damage in the corpus callosum is prevalent in multiple sclerosis (MS). Although callosal damage is associated with disrupted functional connectivity between hemispheres, it is unclear how this relates to cognitive and physical disability. We investigated this phenomenon using advanced measures of microstructural integrity in the corpus callosum and surface-based homologous inter-hemispheric connectivity (sHIC) in the cortex. We found that sHIC was significantly decreased in primary motor, somatosensory, visual, and temporal cortical areas in a group of 36 participants with MS (29 relapsing–remitting, 4 secondary progressive MS, and 3 primary-progressive MS) compared with 42 healthy controls (cluster level, p < 0.05). In participants with MS, global sHIC correlated with fractional anisotropy and restricted volume fraction in the posterior segment of the corpus callosum (r = 0.426, p = 0.013; r = 0.399, p = 0.020, respectively). Lower sHIC, particularly in somatomotor and posterior cortical areas, was associated with cognitive impairment and higher disability scores on the Expanded Disability Status Scale (EDSS). We demonstrated that higher levels of sHIC attenuated the effects of posterior callosal damage on physical disability and cognitive dysfunction, as measured by the EDSS and Brief Visuospatial Memory Test-Revised (interaction effect, p < 0.05). We also observed a positive association between global sHIC and years of education (r = 0.402, p = 0.018), supporting the phenomenon of “brain reserve” in MS. Our data suggest that preserved sHIC helps prevent cognitive and physical decline in MS.
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影响因子：
14.5
作者：
Evangelou, N;Konz, D;Matthews, PM
通讯作者：
Matthews, PM
DOI：
10.1073/pnas.1110024108
发表时间：
2011-11-22
影响因子：
11.1
作者：
Hawellek, David J.;Hipp, Joerg F.;Engel, Andreas K.
通讯作者：
Engel, Andreas K.
影响因子：
5.7
作者：
Anticevic, Alan;Dierker, Donna L.;Barch, Deanna M.
通讯作者：
Barch, Deanna M.
影响因子：
3.5
作者：
Bergendal, G.;Martola, J.;Almkvist, O.
通讯作者：
Almkvist, O.
影响因子：
14.5
作者：
Cutter, GR;Baier, ML;Willoughby, E
通讯作者：
Willoughby, E