Metabolic syndrome and diabetes, alone and in combination, as predictors of cardiovascular disease mortality among men.
Metabolic syndrome and diabetes, alone and in combination, as predictors of cardiovascular disease mortality among men.
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DOI：
10.2337/dc08-1871
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发表时间：
2009-07
期刊：
影响因子：
16.2
通讯作者：
Blair SN
中科院分区：
文献类型：
--
作者：
Church TS;Thompson AM;Katzmarzyk PT;Sui X;Johannsen N;Earnest CP;Blair SN
研究仅患有糖尿病、仅患有代谢综合征以及代谢综合征和糖尿病并存的男性的心血管疾病（CVD）死亡风险。我们在有氧运动中心纵向研究（ACLS）（平均± SD年龄45.1 ± 10.2岁）的男性中通过代谢综合征和糖尿病状态检查CVD死亡风险。参与者分为既无糖尿病也无代谢综合征（n = 23，770），仅代谢综合征（n = 8，780），仅糖尿病（n = 532）或两者兼而有之（n = 1，097）。随访持续时间为14.6 ± 7.0年，共有483，079人-年暴露和1，085例CVD死亡。年龄、检查年和吸烟调整的CVD死亡率（每1,000人年）在既无代谢综合征也无糖尿病、仅代谢综合征、仅糖尿病以及两者均无的男性中分别为1.9、3.3、5.5和6.5。仅代谢综合征（风险比1.8 [95%CI 1.5-2.0]）、仅糖尿病（风险比2.9 [2.1-4.0]）和两者均患（风险比3.4 [2.8-4.2]）的男性CVD死亡率高于两者均不患的男性。在糖尿病患者中，代谢综合征的存在与较高的CVD死亡风险无关（1.2 [0.8-1.7]）。相比之下，糖尿病的存在大大增加了代谢综合征患者的CVD死亡风险（2.1 [1.7-2.6]）。糖尿病的存在与高出三倍的CVD死亡风险相关，代谢综合征状态并没有改变这种风险。我们的研究结果支持了这样一个事实，即医生应该积极地在所有糖尿病患者中使用降低CVD风险的治疗，而不管代谢综合征的状态如何。
To examine cardiovascular disease (CVD) mortality risk in men with diabetes only, metabolic syndrome only, and concurrent metabolic syndrome and diabetes. We examined CVD mortality risk by metabolic syndrome and diabetes status in men from the Aerobics Center Longitudinal Study (ACLS) (mean ± SD age 45.1 ± 10.2 years). Participants were categorized as having neither diabetes nor metabolic syndrome (n = 23,770), metabolic syndrome only (n = 8,780), diabetes only (n = 532), or both (n = 1,097). The duration of follow-up was 14.6 ± 7.0 years with a total of 483,079 person-years of exposure and 1,085 CVD deaths. Age-, examination year–, and smoking-adjusted CVD death rates (per 1,000 man-years) in men with neither metabolic syndrome nor diabetes, metabolic syndrome only, diabetes only, and both were 1.9, 3.3, 5.5, and 6.5, respectively. CVD mortality was higher in men with metabolic syndrome only (hazard ratio 1.8 [95% CI 1.5–2.0]), diabetes only (2.9 [2.1–4.0]), and both (3.4 [2.8–4.2]) compared with men with neither. The presence of metabolic syndrome was not associated (1.2 [0.8–1.7]) with higher CVD mortality risk in individuals with diabetes. In contrast, the presence of diabetes substantially increased (2.1 [1.7–2.6]) CVD mortality risk in individuals with metabolic syndrome. The presence of diabetes was associated with a threefold higher CVD mortality risk, and metabolic syndrome status did not modify this risk. Our findings support the fact that physicians should be aggressive in using CVD risk–reducing therapies in all diabetic patients regardless of metabolic syndrome status.
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影响因子：
37.8
作者：
Hunt, KJ;Resendez, RG;Stern, MP
通讯作者：
Stern, MP
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