Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer.
Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer.
复制标题
DOI：
10.3389/fphar.2013.00080
复制
发表时间：
2013
影响因子：
5.6
通讯作者：
Johnson JJ
中科院分区：
文献类型：
--
作者：
Li G;Thomas S;Johnson JJ
山竹(Garcinia Mangostana)是一种原产于东南亚的热带水果，长期以来一直被报道含有多种保健功能。这种水果含有丰富的口山酮，这是一种具有独特的三环芳环系统的多酚化合物，它的生物活性包括抗癌活性在很大程度上是由它引起的。在此，我们描述了包括α-芒果苷在内的山竹多酚口服酮对乳腺癌和前列腺癌的抗癌活性及其作用机制。到目前为止，在体内外已经发现提取物和单体酮对癌细胞具有诱导凋亡和抑制增殖的作用。根据已报道的结果，有明确的证据表明，这些多酚类物质针对参与细胞周期调节和细胞凋亡的多个信号通路。需要进一步的工作来了解其促进健康的潜力和前列腺癌和乳腺癌化学预防的潜在药物发现。
The mangosteen (Garcinia mangostana) is a tropical fruit native to Southeast Asia and has long been reported to contain multiple health promoting properties. This fruit is an abundant source of xanthones, a class of polyphenolic compounds with a distinctive tricyclic aromatic ring system and is largely responsible for its biological activities including anti-cancer activity. Herein we describe the anti-cancer activity and mechanisms of mangosteen polyphenolic xanthones including α-Mangostin against breast cancer and prostate cancer. So far, extracts and individual xanthones have been found to induce apoptosis and inhibit proliferation on cancer cells in vitro and in vivo. Based on the reported findings there is clear evidence that these polyphenols target multiple signaling pathways involved in cell cycle modulation and apoptosis. Further work is required to understand its potential for health promotion and potential drug discovery for prostate and breast cancer chemoprevention.
登录
查看更多内容
影响因子：
9.3
作者：
Shibata MA;Iinuma M;Morimoto J;Kurose H;Akamatsu K;Okuno Y;Akao Y;Otsuki Y
通讯作者：
Otsuki Y
影响因子：
5.1
作者：
Han, Ah-Reum;Kim, Jeong-Ah;Lantvit, Daniel D.;Leonardus, B. S. Kardono;Riswan, Soedarsono;Chai, Heebyung;de Blanco, Esperanza J. Carcache;Farnsworth, Norman R.;Swanson, Steven M.;Kinghorn, A. Douglas
通讯作者：
Kinghorn, A. Douglas
影响因子：
6.1
作者：
Jung, HA;Su, BN;Kinghorn, AD
通讯作者：
Kinghorn, AD
影响因子：
5.4
作者：
Moongkarndi, P;Kosem, N;Neungton, N
通讯作者：
Neungton, N
影响因子：
3.7
作者：
Johnson, Jeremy J.;Syed, Deeba N.;Mukhtar, Hasan
通讯作者：
Mukhtar, Hasan