An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.
An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.
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DOI：
10.1111/j.1749-6632.2011.06213.x
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发表时间：
2011-11
影响因子：
5.2
通讯作者：
Rosen CJ
中科院分区：
文献类型：
--
作者：
Guntur AR;Kawai M;Le P;Bouxsein ML;Bornstein S;Green CB;Rosen CJ
昼夜节律蛋白在调节全身代谢和骨转换中的作用已被详细研究，并导致发现了涉及核心基因Clock，Bmal 1，Per和Cry的计时基本系统。Nocturnin基因是一种昼夜节律调控基因，通过其关键基因的去腺苷酸化和PPARγ的胞内转运，在脂肪形成中发挥重要作用。它在骨生成中的作用以前没有被详细研究。在本报告中，我们研究了在存在和不存在Nocturnin的情况下的体外和体内成骨作用，并表明Nocturnin的缺失增强了骨形成，并且可以挽救罗格列酮诱导的小鼠骨丢失。Nocturnin的昼夜节律可能是骨髓基质细胞命运的重要因素。
The role of circadian proteins in regulating whole body metabolism and bone turnover has been studied in detail and has led to the discovery of an elemental system for timekeeping involving the core genes Clock, Bmal1, Per, and Cry. Nocturnin, a peripheral circadian-regulated gene has been shown to play a very important role in regulating adipogenesis by deadenylation of key mRNAs and intra-cytoplasmic transport of PPARγ. The role that it plays in osteogenesis has previously not been studied in detail. In this report we examined in vitro and in vivo osteogenesis in the presence and absence of Nocturnin and show that loss of Nocturnin enhances bone formation and can rescue Rosiglitazone induced bone loss in mice. The circadian rhythm of Nocturnin is likely to be an essential element of marrow stromal cell fate.
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影响因子：
4.6
作者：
Guntur, Anyonya R.;Reinhold, Martina I.;Naski, Michael C.
通讯作者：
Naski, Michael C.
DOI：
10.1073/pnas.93.25.14884
发表时间：
1996-12-10
影响因子：
11.1
作者：
Green, CB;Besharse, JC
通讯作者：
Besharse, JC
影响因子：
5.2
作者：
Kawai M;Green CB;Horowitz M;Ackert-Bicknell C;Lecka-Czernik B;Rosen CJ
通讯作者：
Rosen CJ
DOI：
10.1002/tera.1420220306
发表时间：
1980-01-01
期刊：
TERATOLOGY
影响因子：
--
作者：
MCLEOD, MJ
通讯作者：
MCLEOD, MJ
DOI：
10.1073/pnas.1000788107
发表时间：
2010-06-08
影响因子：
11.1
作者：
Kawai, Masanobu;Green, Carla B.;Rosen, Clifford J.
通讯作者：
Rosen, Clifford J.