Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects.
Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects.
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DOI：
10.1016/j.thromres.2012.12.006
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发表时间：
2013-03
影响因子：
7.5
通讯作者：
Diaz JA
中科院分区：
文献类型：
--
作者：
Patterson KA;Zhang X;Wrobleski SK;Hawley AE;Lawrence DA;Wakefield TW;Myers DD;Diaz JA
他汀类药物，特别是瑞舒伐他汀，最近在静脉血栓形成的情况下变得相关。本研究的目的是研究瑞舒伐他汀对高脂血症小鼠静脉血栓形成的非降脂作用。建立小鼠下腔静脉结扎静脉血栓模型。血栓形成48h后灌胃给予生理盐水或瑞舒伐他汀5mg/kg。血栓形成后3、6小时和2天分别取血、下腔静脉、血栓和肝脏。测量血栓重量、炎症标志物、纤溶酶原激活物抑制剂-1的表达和血浆水平，并评估中性粒细胞向下腔静脉的迁移。瑞舒伐他汀显著降低血栓重量、纤溶酶原激活物抑制剂-1的表达和血浆水平、白细胞介素-6通路相关分子的表达以及中性粒细胞向静脉壁的迁移。本研究支持瑞舒伐他汀对高脂血症小鼠静脉血栓形成的有益作用，因为它具有非降脂作用。
Statins, particularly rosuvastatin, have recently become relevant in the setting of venous thrombosis. The objective of this study was to study the non-lipid lowering effects of rosuvastatin in venous thrombosis in mice with hyperlipidemia. An inferior vena cava ligation model of venous thrombosis in mice was utilized. Saline or 5mg/kg of rosuvastatin was administered by gavage 48hs previous thrombosis. Blood, the inferior vena cava, thrombus, and liver were harvested 3, 6 hours, and 2 days post-thrombosis. Thrombus weight, inflammatory markers, and plasminogen activator inhibitor-1 expression and plasma levels were measured and neutrophil migration to the IVC was assessed. Rosuvastatin significantly decreased thrombus weight, plasminogen activator inhibitor-1 expression and plasma levels, expression of molecules related to the interleukin-6 pathway, and neutrophil migration into the vein wall. This work supports the beneficial effects of rosuvastatin on venous thrombosis in mice with hyperlipidemia due to its non-lipid lowering effects.
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DOI：
10.1177/1076029611405032
发表时间：
2011-08
期刊：
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
影响因子：
--
作者：
Ramacciotti E;Blackburn S;Hawley AE;Vandy F;Ballard-Lipka N;Stabler C;Baker N;Guire KE;Rectenwald JE;Henke PK;Myers DD Jr;Wakefield TW
通讯作者：
Wakefield TW
影响因子：
5.3
作者：
Laumen, Helmut;Skurk, Thomas;Hauner, Hans
通讯作者：
Hauner, Hans
影响因子：
1.2
作者：
Diaz, Jose A.;Wrobleski, Shirley K.;Myers, Daniel D.
通讯作者：
Myers, Daniel D.
DOI：
10.1161/01.atv.0000159701.24372.49
发表时间：
2005-05-01
影响因子：
8.7
作者：
Dong, J;Fujii, S;Kitabatake, A
通讯作者：
Kitabatake, A
影响因子：
11.4
作者：
Arendt, BK;Velazquez-Dones, A;Jelinek, DF
通讯作者：
Jelinek, DF