IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis.
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis.
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DOI：
10.1093/nar/gkn316
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发表时间：
2008-07-01
影响因子：
14.9
通讯作者：
Giudicelli V
中科院分区：
文献类型：
--
作者：
Brochet X;Lefranc MP;Giudicelli V
IMGT/V-QUEST是高度定制和集成的系统，用于免疫球蛋白（IG）和T细胞受体（TR）重排核苷酸序列的标准化分析。IMGT/V-QUEST通过与IMGT参考目录的种系IG和TR基因和等位基因序列比对来鉴定可变（V）、多样性（D）和连接（J）基因和等位基因。新的功能是通过在Java中完全重写而添加的。IMGT/V-QUEST在一次运行中分析批次序列（最多50个）。IMGT/V-QUEST描述了V-REGION突变，并确定了最接近的生殖系V基因中的热点位置。IMGT/V-QUEST可以通过参考IMGT唯一编号来检测提交序列中的插入和缺失。IMGT/V-QUEST集成了IMGT/JunctionAnalysis，用于详细分析V-J和V-D-J连接，并集成了IMGT/Automat，用于完整的V-J-和V-D-J-REGION注释。IMGT/V-QUEST在“详细视图”中单独显示每个提交序列的结果和比对，在“合成视图”中显示在给定运行中表达相同V基因和等位基因的序列的比对。“高级参数”允许根据用户的兴趣修改IMGT/V-QUEST和IMGT/JunctionAnalysis使用的默认参数。IMGT/V-QUEST可在http://imgt.cines.fr上免费获得，用于学术研究
IMGT/V-QUEST is the highly customized and integrated system for the standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide sequences. IMGT/V-QUEST identifies the variable (V), diversity (D) and joining (J) genes and alleles by alignment with the germline IG and TR gene and allele sequences of the IMGT reference directory. New functionalities were added through a complete rewrite in Java. IMGT/V-QUEST analyses batches of sequences (up to 50) in a single run. IMGT/V-QUEST describes the V-REGION mutations and identifies the hot spot positions in the closest germline V gene. IMGT/V-QUEST can detect insertions and deletions in the submitted sequences by reference to the IMGT unique numbering. IMGT/V-QUEST integrates IMGT/JunctionAnalysis for a detailed analysis of the V-J and V-D-J junctions, and IMGT/Automat for a full V-J- and V-D-J-REGION annotation. IMGT/V-QUEST displays, in ‘Detailed view’, the results and alignments for each submitted sequence individually and, in ‘Synthesis view’, the alignments of the sequences that, in a given run, express the same V gene and allele. The ‘Advanced parameters’ allow to modify default parameters used by IMGT/V-QUEST and IMGT/JunctionAnalysis according to the users’ interest. IMGT/V-QUEST is freely available for academic research at http://imgt.cines.fr
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影响因子：
3.9
作者：
Duroux, Patrice;Kaas, Quentin;Giudicelli, Veronique
通讯作者：
Giudicelli, Veronique
影响因子：
4.4
作者：
Souto-Carneiro, MM;Longo, NS;Lipsky, PE
通讯作者：
Lipsky, PE
影响因子：
5.8
作者：
Volpe, JM;Cowell, LG;Kepler, TB
通讯作者：
Kepler, TB
影响因子：
14.9
作者：
Giudicelli, Veronique;Duroux, Patrice;Ginestoux, Chantal;Folch, Geraldine;Jabado-Michaloud, Joumana;Chaume, Denys;Lefranc, Marie-Paule
通讯作者：
Lefranc, Marie-Paule
影响因子：
5.8
作者：
Giudicelli, V;Lefranc, MP
通讯作者：
Lefranc, MP