Temporally-precise disruption of prefrontal cortex informed by the timing of beta bursts impairs human action-stopping.
Temporally-precise disruption of prefrontal cortex informed by the timing of beta bursts impairs human action-stopping.
复制标题
由贝塔爆发的时机所通知的前额叶皮质在时间上的精确破坏会损害人类的动作停止。
DOI：
10.1016/j.neuroimage.2020.117222
复制
发表时间：
2020-11-15
期刊：
影响因子：
5.7
通讯作者：
Aron AR
中科院分区：
文献类型：
--
作者：
Hannah R;Muralidharan V;Sundby KK;Aron AR
人类的行动停止被认为依赖于前额叶-基底神经节-丘脑皮质网络，右下额叶皮质（rIFC）在实施的早期阶段发挥关键作用。在这里，我们在涉及健康人类参与者的实验中寻找这一想法的因果证据。我们首先表明，动作停止之前，脑电活动的爆发在β带在前额电极，puperriIFC，这些突发的时间与延迟停止在一个单一的试验水平：较早的突发与更快的停止。由此我们推断，在β爆发时rIFC的完整性可能对成功停止至关重要。然后，我们使用fMRI引导的经颅磁刺激（TMS）在β爆发的近似时间破坏rIFC。刺激延长了停止lasting，而且，延长是最明显的个人的脉冲出现更接近假定的时间β爆发。这些结果有助于验证的神经结构和动作停止的时间动态模型。他们还强调了前额叶β爆发的有用性，以索引一个明显重要的停止子过程，其时间可能有助于解释冲动控制的个体内和个体间的差异。
Human action-stopping is thought to rely on a prefronto-basal ganglia-thalamocortical network, with right inferior frontal cortex (rIFC) posited to play a critical role in the early stage of implementation. Here we sought causal evidence for this idea in experiments involving healthy human participants. We first show that action-stopping is preceded by bursts of electroencephalographic activity in the beta band over prefrontal electrodes, putatively rIFC, and that the timing of these bursts correlates with the latency of stopping at a single-trial level: earlier bursts are associated with faster stopping. From this we reasoned that the integrity of rIFC at the time of beta bursts might be critical to successful stopping. We then used fMRI-guided transcranial magnetic stimulation (TMS) to disrupt rIFC at the approximate time of beta bursting. Stimulation prolonged stopping latencies and, moreover, the prolongation was most pronounced in individuals for whom the pulse appeared closer to the presumed time of beta bursting. These results help validate a model of the neural architecture and temporal dynamics of action-stopping. They also highlight the usefulness of prefrontal beta bursts to index an apparently important sub-process of stopping, the timing of which might help explain within- and between-individual variation in impulse control.
登录
查看更多内容
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
3
作者：
Cohen, Michael X.
通讯作者：
Cohen, Michael X.
影响因子：
3.2
作者：
Chambers, CD;Bellgrove, MA;Mattingley, JB
通讯作者：
Mattingley, JB
影响因子：
10.6
作者：
Aron, Adam R.
通讯作者：
Aron, Adam R.
影响因子：
3.8
作者：
Bakdash JZ;Marusich LR
通讯作者：
Marusich LR