Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease.
Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease.
复制标题
视网膜健康和疾病中的球类视内素结合蛋白（IRBP）。
DOI：
10.3389/fncel.2020.577935
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发表时间：
2020
影响因子：
5.3
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Zeng S;Zhang T;Madigan MC;Fernando N;Aggio-Bruce R;Zhou F;Pierce M;Chen Y;Huang L;Natoli R;Gillies MC;Zhu L
光感受器间视黄醇结合蛋白（IRBP），也称为视黄醇结合蛋白3（RBP3），是光感受器特异性分泌的亲脂性糖蛋白。 IRBP 富含光感受器间基质 (IPM) 并由视网膜色素上皮 (RPE) 回收，对所有脊椎动物的视力至关重要，因为它有助于视黄醇在视觉循环中的转移。它还有助于在视网膜色素上皮和光感受器之间运输脂质。 IRBP 的硫醇依赖性抗氧化活性维持正常视网膜中微妙的氧化还原平衡。因此，怀疑其功能障碍在许多视网膜疾病中发挥作用。我们在此回顾了IRBP在视网膜健康和疾病中的最新研究，包括动物模型和人类视网膜在视网膜应激下IRBP的功能和调节。我们还探索了靶向 IRBP 在视网膜疾病中的治疗潜力。尽管仍然存在一些技术障碍，但操纵视网膜中 IRBP 的表达可能会挽救或预防许多视网膜疾病中的光感受器变性。
Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by photoreceptors. Enriched in the interphotoreceptor matrix (IPM) and recycled by the retinal pigment epithelium (RPE), IRBP is essential for the vision of all vertebrates as it facilitates the transfer of retinoids in the visual cycle. It also helps to transport lipids between the RPE and photoreceptors. The thiol-dependent antioxidant activity of IRBP maintains the delicate redox balance in the normal retina. Thus, its dysfunction is suspected to play a role in many retinal diseases. We have reviewed here the latest research on IRBP in both retinal health and disease, including the function and regulation of IRBP under retinal stress in both animal models and the human retina. We have also explored the therapeutic potential of targeting IRBP in retinal diseases. Although some technical barriers remain, it is possible that manipulating the expression of IRBP in the retina will rescue or prevent photoreceptor degeneration in many retinal diseases.
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影响因子：
4.4
作者：
Betts-Obregon, Brandi S.;Gonzalez-Fernandez, Federico;Tsin, Andrew T.
通讯作者：
Tsin, Andrew T.
影响因子：
4.1
作者：
DAS, SR;BHARDWAJ, N;GOURAS, P
通讯作者：
GOURAS, P
影响因子：
4.8
作者：
Chen, Yu;Okano, Kiichiro;Palczewski, Krzysztof
通讯作者：
Palczewski, Krzysztof
影响因子：
3.3
作者：
CROUCH, RK;HAZARD, ES;CORSON, DW
通讯作者：
CORSON, DW
影响因子：
2.9
作者：
CARLSON, A;BOK, D
通讯作者：
BOK, D