International patterns and trends in ovarian cancer incidence, overall and by histologic subtype.
International patterns and trends in ovarian cancer incidence, overall and by histologic subtype.
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DOI：
10.1002/ijc.30676
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发表时间：
2017-06-01
影响因子：
6.4
通讯作者：
Trabert B
中科院分区：
文献类型：
--
作者：
Coburn SB;Bray F;Sherman ME;Trabert B
在国际上，卵巢癌是第7大癌症诊断和第8大妇女癌症死亡原因。卵巢癌发病率因地区而异，特别是在比较高收入国家和低收入国家时。生殖因素的时间变化加上诊断标准的变化可能影响了卵巢癌的发病率趋势和组织学亚型的相对发病率。因此，我们使用五大洲癌症发病率数据库（CI5plus）和CI5X（卷X）数据库的IV-IX卷评估了卵巢癌发病率总体（1973-1977年至2003-2007年）和组织学亚型（1988-1992年至2003-2007年）的趋势。计算卵巢癌发病率趋势的年百分比变化，并将个别国家的组织学亚型率与总体国际发病率进行比较。尽管东欧/南欧（如波兰：年百分比变化（APC） 1.6%, p=0.02）和亚洲（如日本：APC 1.7%, p=0.01）的发病率显著增加，但各地区的卵巢癌发病率保持稳定，北欧（如丹麦：APC - 0.7%, p=0.01）和北美（如美国白人：APC - 0.9%, p<0.01）的发病率有所下降。各国组织学亚型的相对比例相似，除了亚洲国家，透明细胞癌和子宫内膜样癌占比较高，浆液性癌占比较低。卵巢癌发病时间趋势的地理差异和组织学亚型分布的差异可能部分由生殖和遗传因素解释。因此，应继续监测组织学特异性卵巢癌，以进一步了解这种肿瘤的病因。
Internationally, ovarian cancer is the 7th leading cancer diagnosis and 8th leading cause of cancer mortality among women. Ovarian cancer incidence varies by region, particularly when comparing high versus low income countries. Temporal changes in reproductive factors coupled with shifts in diagnostic criteria may have influenced incidence trends of ovarian cancer and relative rates by histologic subtype. Accordingly, we evaluated trends in ovarian cancer incidence overall (1973–1977 to 2003–2007) and by histologic subtype (1988–1992 to 2003–2007) using volumes IV-IX of the Cancer Incidence in Five Continents database (CI5plus) and CI5X (volume X) database. Annual percent changes were calculated for ovarian cancer incidence trends, and rates of histologic subtypes for individual countries were compared to overall international incidence. Ovarian cancer incidence rates were stable across regions, although there were notable increases in Eastern/Southern Europe (e.g. Poland: Annual Percent Change (APC) 1.6%, p=0.02) and Asia (e.g. Japan: APC 1.7%, p=0.01) and decreases in Northern Europe (e.g. Denmark: APC −0.7%, p=0.01) and North America (e.g. US Whites: APC −0.9%, p<0.01). Relative proportions of histologic subtypes were similar across countries, except for Asian nations, where clear cell and endometrioid carcinomas comprised a higher proportion of the rate and serous carcinomas comprised a lower proportion of the rate than the worldwide distribution. Geographic variation in temporal trends of ovarian cancer incidence and differences in the distribution of histologic subtype may be partially explained by reproductive and genetic factors. Thus, histology-specific ovarian cancer should continue to be monitored to further understand the etiology of this neoplasm.
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影响因子：
5
作者：
Missmer, SA;Hankinson, SE;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
168.9
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Beral, V.;Doll, R.;Risch, H. A.
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Risch, H. A.
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158.5
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Modan, B;Hartge, P;Piura, B
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作者：
DEVESA, SS;DONALDSON, J;FEARS, T
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FEARS, T
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3.3
作者：
Gilks, C. Blake;Prat, Jaime
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Prat, Jaime