The spike-timing dependence of plasticity.

The spike-timing dependence of plasticity.
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DOI:
10.1016/j.neuron.2012.08.001
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发表时间:
2012-08-23
期刊:
影响因子:
16.2
通讯作者:
Feldman DE
Feldman DE
中科院分区:
医学1区
文献类型:
--
作者:
Feldman DE

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在锋电位时间依赖可塑性(STDP)中,突触前和突触后锋电位之间的顺序和精确的时间间隔决定了长时程增强(LTP)或抑制(LTD)的信号和幅度。STDP被广泛用于电路级可塑性,发展和学习的模型。然而,尖峰时间只是控制可塑性诱导的几个因素之一(包括放电率、突触协同性和去极化),其相对重要性在突触和活动机制中各不相同。本文综述了STDP的形式,细胞机制和患病率,并评估证据表明,尖峰时间是一个重要的决定因素,在体内可塑性。
In spike timing-dependent plasticity (STDP), the order and precise temporal interval between presynaptic and postsynaptic spikes determine the sign and magnitude of long-term potentiation (LTP) or depression (LTD). STDP is widely utilized in models of circuit-level plasticity, development, and learning. However, spike timing is just one of several factors (including firing rate, synaptic cooperativity, and depolarization) that govern plasticity induction, and its relative importance varies across synapses and activity regimes. This review summarizes the forms, cellular mechanisms, and prevalence of STDP, and evaluates the evidence that spike timing is an important determinant of plasticity in vivo.
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