Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
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DOI：
10.4049/jimmunol.1103433
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发表时间：
2012-04-01
期刊：
影响因子：
--
通讯作者：
Dimitroff CJ
中科院分区：
文献类型：
--
作者：
Cedeno-Laurent F;Opperman M;Barthel SR;Kuchroo VK;Dimitroff CJ
Galectin-1 (Gal-1), aβ-galactoside-binding protein, can alter fate and effector function of T helper (Th) cells; however, little is known about how Gal-1 induces Th cell differentiation. Here, we show that both uncommitted and polarized Th cells bound by Gal-1 expressed an immunoregulatory signature defined by IL-10. IL-10synthesis was stimulated by direct Gal-1 engagement to cell surface glycoproteins, principally CD45, on activated Th cells and enhanced by IL-21 expression through the c-Maf/aryl hydrocarbon receptor (AhR) pathway, independent of antigen-presenting cells. Gal-1-induced IL-10+ Tcells efficiently suppressed T cell proliferation and T-cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. Collectively, these findings show how Gal-1 functions as a major glycome determinant regulating Th cell development, inflammation and tumor immunity.
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影响因子：
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DOI：
10.1073/pnas.0706017104
发表时间：
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影响因子：
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作者：
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影响因子：
32.4
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通讯作者：
Grusby, MJ