Expression of c-Fos-like immunoreactivity in the feline brainstem in response to isometric muscle contraction and baroreceptor reflex changes in arterial pressure
Expression of c-Fos-like immunoreactivity in the feline brainstem in response to isometric muscle contraction and baroreceptor reflex changes in arterial pressure
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猫脑干中 c-Fos 样免疫反应性的表达，响应等长肌肉收缩和动脉压压力感受器反射变化
DOI：
10.1016/s0006-8993(99)02217-9
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发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
D. Hoover
中科院分区：
文献类型：
--
作者：
C. Williams;Stephen D. Loyd;Toby A. Hampton;D. Hoover
本研究比较了是否激活肌肉的ergoreceptor传入引起的等长肌肉收缩，激活压力感受器传入引起的静脉注射苯肾上腺素，或压力感受器传入失活，引起颈动脉闭塞，在脑干区引起类似的模式的c-Fos诱导。用α-氯醛糖麻醉成年猫，在每种情况下，实验干预均导致动脉血压升高。有两组对照实验：在这两组实验中，动物都经历了相同的外科手术，但在整个研究中要么保持休息，要么刺激胫神经，就像收缩组一样，在肌肉麻痹后用筒箭毒碱刺激。在程序之后，动物休息90分钟以允许c-Fos的神经元表达。对照猫在脑干中显示出非常少的c-Fos免疫反应性（c-Fos-ir）。肌肉收缩引起c-Fos-ir主要表达于孤束核、外侧网状核、外侧被盖区、前庭核、面后下核、三叉神经脊束和中脑导水管周围灰质外侧区（P0.5 -1.0）。大多数c-Fos-ir被发现在脑干区的对侧收缩的肌肉。此外，肌肉收缩可诱导同侧脊髓L 6-S1节段后角c-Fos-ir表达。苯肾上腺素灌注引起c-Fos-ir表达在孤束核，三叉神经脊束，孤束，迷走神经背侧运动核。导水管周围灰质未见c-Fos-ir。颈动脉闭塞诱导c-Fos-ir表达在最后区，孤束核，孤束，三叉神经脊束。表达是双边的。表现出c-Fos-ir的区域对应于先前报道的响应于肌肉收缩或颈动脉闭塞而释放各种神经肽的位点。这些结果表明，运动加压反射和压力反射激活相似，但不完全相同，在脑干的网站。
This study compared whether activation of muscle ergoreceptor afferents caused by isometric muscle contraction, activation of baroreceptor afferents induced by i.v. infusion of phenylephrine, or baroreceptor afferent inactivation, caused by carotid artery occlusion, elicit similar patterns of c-Fos induction in brainstem areas. Adult cats were anesthetized with α-chloralose, and in each case, the experimental intervention caused an increase in the arterial blood pressure. There were two sets of control experiments: in both, animals underwent the same surgical procedures but then either remained at rest for the entire study, or the tibial nerve was stimulated, as in the contraction group, following muscle paralysis with tubocurarine. Following the procedures, animals rested for 90 min to allow neuronal expression of c-Fos. Control cats showed very little c-Fos immunoreactivity (c-Fos-ir) in the brainstem. Muscle contraction induced c-Fos-ir expression mainly in the nucleus tractus solitarius, lateral reticular nucleus, lateral tegmental field, vestibular nucleus, subretrofacial nucleus, spinal trigeminal tract and in a lateral region of the periaqueductal grey (P 0.5–1.0). The majority of the c-Fos-ir was found in brainstem areas contralateral to the contracted muscle. In addition, muscle contraction induced c-Fos-ir in the dorsal horns of spinal segments L6–S1on the ipsilateral side of the spinal cord. Phenylephrine infusion caused c-Fos-ir expression in the nucleus tractus solitarius, spinal trigeminal tract, solitary tract, and dorsal motor nucleus of the vagus. No c-Fos-ir was apparent in the periaqueductal grey. Carotid occlusions induced c-Fos-ir expression in the area postrema, nucleus tractus solitarius, solitary tract, and spinal trigeminal tract. Expression was bilateral. Areas that exhibited c-Fos-ir correspond to sites previously reported to release various neuropeptides in response to muscle contraction or carotid occlusions. These results indicate that the exercise pressor reflex and baroreflex activate similar, but not completely identical, sites in the brainstem.
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麻醉猫加压反射运动期间脊髓中 P 物质的释放。
DOI：
10.1113/jphysiol.1993.sp019460
发表时间：
1993
期刊：
The Journal of physiology
影响因子：
--
作者：
Wilson,LB;Fuchs,IE;Matsukawa,K;Mitchell,JH;Wall,PT
通讯作者：
Wall,PT
GABA 介导的压力感受器抑制网状脊髓神经元。
DOI：
10.1152/ajpregu.1985.249.6.r672
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Sun,MK;Guyenet,PG
通讯作者：
Guyenet,PG
后肢躯体传入孤束核的时间依赖性抑制。
影响因子：
2.5
作者：
Toney,GM;Mifflin,SW
通讯作者：
Mifflin,SW
猫肌肉收缩的升压反应：尾侧和头侧腹外侧延髓的贡献。
影响因子：
--
作者：
Iwamoto,GA;Waldrop,TG;Bauer,RM;Mitchell,JH
通讯作者：
Mitchell,JH