Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses.
Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses.
复制标题
通过概率纤维束成像和基于连接的分析确定非神经精神系统性红斑狼疮患者白质结构网络的改变
DOI：
10.1016/j.nicl.2016.12.021
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发表时间：
2017
影响因子：
4.2
通讯作者：
Feng, Yanqiu
中科院分区：
文献类型：
--
作者：
Xu, Man;Tan, Xiangliang;Zhang, Xinyuan;Guo, Yihao;Mei, Yingjie;Feng, Qianjin;Xu, Yikai;Feng, Yanqiu
关键词：
系统性红斑狼疮 (SLE) 是一种女性为主的慢性炎症性自身免疫性疾病，可影响中枢神经系统并表现出神经精神症状。在没有神经精神症状的 SLE 患者（非 NPSLE）中，最近的弥散张量成像研究显示他们大脑中存在白质异常。本研究通过使用概率纤维束成像和基于连接的分析，研究了非 NPSLE 患者的整个大脑白质结构连接。检查了 29 名非 NPSLE 患者和 29 名健康对照 (HC) 的全脑结构网络。结构网络是通过区域间概率连通性构建的。采用图论分析来研究拓扑特性，并采用基于网络的统计来评估非 NPSLE 患者和对照之间区域间连接的变化。与 HC 相比，非 NPSLE 患者的全局和局部网络效率显着降低，并且特征路径长度增加。这一发现表明全球一体化和本地专业化受到损害。此外，非 NPSLE 患者额叶、枕叶和扣带区的区域特性（节点效率和程度）发生显着变化，且与疾病活动指数呈负相关。在患者组中，通过节点度测量的枢纽的分布模式发生了改变。最后，非 NPSLE 组的左侧正中扣带回中心成分的结构连接性降低，而左侧楔前叶中心成分和右侧颞叶中叶中心成分的结构连接性增加。这项研究揭示了非 NPSLE 患者白质网络拓扑结构的改变。此外，这项研究还为非 NPSLE 患者功能和神经认知缺陷背后的结构破坏提供了新的见解。非 NPSLE 患者的白质网络的整体整合和局部特化受到破坏。节点特性显着改变的大脑区域主要涉及语言、视觉和 DMN 系统。一些已识别区域的特性与 SLE 疾病活动指数得分呈负相关。在非 NPSLE 患者中，通过淋巴结程度测量的中枢分布模式发生了改变。非 NPSLE 组表现出连通性降低的子网和连通性增加的子网。
Systemic lupus erythematosus (SLE) is a chronic inflammatory female-predominant autoimmune disease that can affect the central nervous system and exhibit neuropsychiatric symptoms. In SLE patients without neuropsychiatric symptoms (non-NPSLE), recent diffusion tensor imaging studies showed white matter abnormalities in their brains. The present study investigated the entire brain white matter structural connectivity in non-NPSLE patients by using probabilistic tractography and connectivity-based analyses. Whole-brain structural networks of 29 non-NPSLE patients and 29 healthy controls (HCs) were examined. The structural networks were constructed with interregional probabilistic connectivity. Graph theory analysis was performed to investigate the topological properties, and network-based statistic was employed to assess the alterations of the interregional connections among non-NPSLE patients and controls. Compared with HCs, non-NPSLE patients demonstrated significantly decreased global and local network efficiencies and showed increased characteristic path length. This finding suggests that the global integration and local specialization were impaired. Moreover, the regional properties (nodal efficiency and degree) in the frontal, occipital, and cingulum regions of the non-NPSLE patients were significantly changed and negatively correlated with the disease activity index. The distribution pattern of the hubs measured by nodal degree was altered in the patient group. Finally, the non-NPSLE group exhibited decreased structural connectivity in the left median cingulate-centered component and increased connectivity in the left precuneus-centered component and right middle temporal lobe-centered component. This study reveals an altered topological organization of white matter networks in non-NPSLE patients. Furthermore, this research provides new insights into the structural disruptions underlying the functional and neurocognitive deficits in non-NPSLE patients. The global integration and local specialization of the white matter networks were disrupted in non-NPSLE patients. The brain regions with significantly altered nodal properties were mainly involved in language, visual, and DMN systems. The properties of some identified regions presented negative correlations with the SLE disease activity index scores. The distribution pattern of the hubs measured by nodal degree was altered in the non-NPSLE patients. The non-NPSLE group exhibited a subnetwork of decreased connectivity and a subnetwork of increased connectivity.
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影响因子：
5.7
作者：
Iturria-Medina, Yasser;Sotero, Roberto C.;Melie-Garcia, Lester
通讯作者：
Melie-Garcia, Lester
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
3.5
作者：
Bellec P;Lavoie-Courchesne S;Dickinson P;Lerch JP;Zijdenbos AP;Evans AC
通讯作者：
Evans AC
影响因子：
2.6
作者：
Jung RE;Caprihan A;Chavez RS;Flores RA;Sharrar J;Qualls CR;Sibbitt W;Roldan CA
通讯作者：
Roldan CA
影响因子：
4.2
作者：
Ercan, Ece;Ingo, Carson;Tritanon, Oranan;Magro-Checa, Cesar;Smith, Alex;Smith, Seth;Huizinga, Tom;van Buchem, Mark A.;Ronen, Itamar
通讯作者：
Ronen, Itamar