Role of tear vasoactive intestinal peptide on dry eyes after laser keratorefractive surgery.
Role of tear vasoactive intestinal peptide on dry eyes after laser keratorefractive surgery.
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DOI：
10.1186/s12886-023-02857-w
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发表时间：
2023-04-20
影响因子：
2
通讯作者：
Zhang, Hong
中科院分区：
文献类型：
--
作者：
Kang, Yang;Hu, Qi;Li, Xue;Guo, Zidan;Wu, Qiong;Zhang, Hong
探讨准分子激光辅助上皮下角膜磨镶术（LASEK）和飞秒激光辅助原位角膜磨镶术（FS-LASIK）术后泪液中血管活性肠肽（VIP）浓度的变化及其相关因素，以及术后不同时期干眼症症状与VIP浓度的可能关系。在这项前瞻性、非随机、纵向队列研究中，分别招募了23名和22名受试者并接受了LASEK和FS-LASIK。在进行完整的眼科检查并收集相关手术数据后，所有受试者在手术前和手术后1天、1周和1个月使用ELISA、泪膜破裂时间、眼染色和眼表疾病指数调查问卷检查其泪液中的VIP浓度。LASEK和FS-LASIK术后泪液VIP浓度均显著升高，术后1周最高（P ≤ 0.05）。泪液VIP浓度与角膜切削深度（AD）呈负相关。干眼症的程度与手术方式及术后恢复时间有关。在FS-LASIK和LASEK受试者中，干眼症主要受术前眼表基础状态和VIP浓度的影响。此外，LASEK受试者中，干眼症与AD呈负相关。VIP被刺激和动员作为屈光手术后的紧急保护和AD影响的创伤模型。可间接提示术后干眼症与神经损伤的必然关系。术后泪液VIP升高缓解干眼症症状，显示其在调节不良损伤刺激中的神经免疫作用。本研究为解决术后干眼症的发病机制提供了一个思路。试验注册号：2021 JS 22。登记日期：2021年5月10日。
To explore the changes in vasoactive intestinal peptide (VIP) concentration in tears post laser-assisted sub-epithelial keratomileusis (LASEK) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) surgeries and related factors, possible association between postoperative dry eye symptoms and VIP concentration in tears, and factors influencing dry eye symptoms after different periods post LASEK and FS-LASIK surgeries. In this prospective, non-randomized, longitudinal cohort study, 23 and 22 subjects were recruited and underwent LASEK and FS-LASIK, respectively. After conducting an intact ophthalmic examination and collecting relevant surgical data, all subjects were examined for VIP concentration in their tears using ELISAs, tear-film breakup time, ocular staining and ocular surface disease index questionnaire before surgery and 1 day, 1 week, and 1 month post-surgery. Tear VIP concentration increased significantly after both LASEK and FS-LASIK, with the highest concentration observed 1 week post-surgery (P ≤ 0.05). Tear VIP concentration correlated negatively with corneal ablation depth (AD). The extent of dry eyes was related to the operation method employed and postoperative recovery period. In FS-LASIK and LASEK subjects, dry eyes were mainly affected by the basic ocular surface status before surgery, and VIP concentration. Furthermore, in LASEK subjects, dry eyes were negatively correlated with AD. VIP was stimulated and mobilized as an emergency protection post-refractive surgery and a trauma model affected by AD. It can indirectly indicate the inevitable relationship between postoperative dry eye and nerve injury. Elevated post-surgery tear VIP relieves dry eye symptoms, showing its neuroimmune role in regulating adverse injury stimulation. The present study provides a solution to the pathogenesis of postoperative dry eyes. The trial registration number: 2021JS22. Date of registration: 10 May 2021.
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影响因子：
1.9
作者：
Salah-Mabed I;Moran S;Perez E;Debellemanière G;Gatinel D
通讯作者：
Gatinel D
影响因子：
3.4
作者：
Gong, Qianwen;Zhang, Shasha;Hu, Liang
通讯作者：
Hu, Liang
DOI：
10.2147/opth.s169091
发表时间：
2018
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Shaaban YM;Badran TAF
通讯作者：
Badran TAF
影响因子：
6.4
作者：
Sabatino, Francesco;Di Zazzo, Antonio;Bonini, Stefano
通讯作者：
Bonini, Stefano
DOI：
10.1007/s00417-015-3120-1
发表时间：
2015-11-01
影响因子：
2.7
作者：
Chao, Cecilia;Stapleton, Fiona;Golebiowski, Blanka
通讯作者：
Golebiowski, Blanka