Common and distinct neural inputs to the medial central nucleus of the amygdala and anterior ventrolateral bed nucleus of stria terminalis in rats.
Common and distinct neural inputs to the medial central nucleus of the amygdala and anterior ventrolateral bed nucleus of stria terminalis in rats.
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DOI：
10.1007/s00429-012-0393-6
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发表时间：
2013-01
影响因子：
3.1
通讯作者：
Rinaman, Linda
中科院分区：
文献类型：
--
作者：
Bienkowski, Michael S.;Rinaman, Linda
杏仁核中央核（CEA）和尾纹侧床核（BST）是高度互联的边缘前脑区域，它们与大脑其他区域共享类似的连通性，协调对内部和环境压力的行为和生理反应。当描述CEA和外侧BST一起作为一个统一的“中央扩展杏仁核”时，它们相似的连通性经常被提及。然而，据报道，CEA和BST在与恐惧、焦虑和社交失败相关的行为和生理反应中发挥着不同的作用，这可能是由于连通性的差异。为了确定CEA和侧BST的共同和独特的输入来源，我们进行了双逆行追踪。将氟金和霍乱毒素β离子导入成年雄性大鼠内侧CEA （CEAm）和前腹外侧BST （BSTvl）。示踪剂标记的神经元在整个大脑中的解剖分布被绘制出来。进一步检查CEAm-和bstvl -投射神经元重叠的区域是否存在双标记神经元。虽然大多数输入到mCEA的区域也会投射到BSTvl，反之亦然，但皮层和感觉系统相关区域对CEAm的投射更为强烈，而运动系统相关区域主要支配BSTvl。双标记神经元轴突侧侧输入CEAm和BSTvl的发生率相对较小（约2 ~ 13%），且在不同区域存在差异，表明CEAm和BSTvl的协同输入程度存在区域差异。CEAm和BSTvl输入的相似性和差异性为这些边缘前脑区域的功能组织提供了新的解剖学见解。
The central nucleus of the amygdala (CEA) and lateral bed nucleus of stria terminalis (BST) are highly interconnected limbic forebrain regions that share similar connectivity with other brain regions that coordinate behavioral and physiological responses to internal and environmental stressors. Their similar connectivity is frequently referred to when describing the CEA and lateral BST together as a unified “central extended amygdala”. However, the CEA and BST reportedly play distinct roles in behavioral and physiological responses associated with fear, anxiety, and social defeat, presumably due to differences in connectivity. To identify common and unique sources of input to the CEA and lateral BST, we performed dual retrograde tracing. Fluorogold and cholera toxin β were iontophoresed into the medial CEA (CEAm) and the anterior ventrolateral BST (BSTvl) of adult male rats. The anatomical distribution of tracer-labeled neurons was mapped throughout the brain. Regions with overlapping populations of CEAm- and BSTvl-projecting neurons were further examined for the presence of double-labeled neurons. Although most regions with input to the mCEA also projected to the BSTvl, and vice versa, cortical and sensory system-related regions projected more robustly to the CEAm, while motor system-related regions primarily innervated the BSTvl. The incidence of double-labeled neurons with collateralized axonal inputs to the CEAm and BSTvl was relatively small (~2 to 13%) and varied across regions, suggesting regional differences in the degree of coordinated CEAm and BSTvl input. The demonstrated similarities and differences in inputs to CEAm and BSTvl provide new anatomical insights into the functional organization of these limbic forebrain regions.
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